Results 11 to 20 of about 34,671 (226)
Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Metformin is 1,1-dimethylbiguanide hydrochloride, is the first-line therapy for type 2 diabetes. Additionally, several studies focused on the role of metformin in antioxidant activities for the treatment of hepatic disorders. The experimentally
Intesar Tarik Numan +2 more
doaj +1 more source
Serum concentrations of valproic acid in people with epilepsy: Clinical implication [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Therapeutic drug monitoring (TDM) allows personalizing the dose of valproic acid in patients with epilepsy to optimize drug therapy, minimize adverse effects and detect interactions.
Angel T. Alvarado +12 more
doaj +1 more source
Severe Valproic Acid Intoxication Responding to Hemodialysis
Journal of Pediatric Emergency and Intensive Care Medicine, 2017 Valproic acid is a commonly used antiepileptic drug which causes intoxication easily due to its narrow therapeutic window. Here, we present a child with valproic acid poisoning who responded to hemodialysis.
Ali Ertuğ Arslanköylü +4 more
doaj +1 more source
Electrochemical Degradation and Thermal Deactivation of Valproic Acid Drug
International Journal of Electrochemical Science, 2021 Electrochemical degradation of valproic acid drug (VAc) was studied by direct and indirect electrochemical oxidation processes using platinum electrode.
Simona Iordache +5 more
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Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children
MCBS (Molecular and Cellular Biomedical Sciences), 2019 Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand.
I Gusti Ngurah Made Suwarba +3 more
doaj +1 more source
Valproic Acid-induced Agranulocytosis
International Journal of Gerontology, 2009 Valproic acid is considered to be the most well-tolerated antiepileptic drug. However, few cases of neutropenia or leukopenia caused by valproic acid have been reported. We present a patient who took valproic acid to treat a complication of brain surgery
Hui-Chuan Hsu +3 more
doaj +1 more source
Clinical and Translational Science, 2023 Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods.
Toshihiko Yoshioka +13 more
doaj +1 more source
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
Prague Medical Report, 2017 We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration ...
Martin Šíma +4 more
doaj +1 more source
Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways
Angewandte Chemie, EarlyView.A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim +3 more
wiley +2 more sources
Antidepressant effects of valproic acid in an animal model of depression
European Pharmaceutical Journal, 2019 Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was
Buzgoova K. +3 more
doaj +1 more source