Valproic acid-induced hyperammonemic encephalopathy: a clinical case
European Psychiatry, 2022 Introduction Valproic acid is a psychotropic drug used for several years, due to its properties as a mood stabilizer, being considered as first-line treatment for bipolar disorder.
M. Felizardo, C. Freitas
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Ellagic acid attenuates liver toxicity induced by valproic acid in rats
Journal of Pharmacological Sciences, 2020 Valproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity.The present study investigated the ...
Noha F. Abdelkader +5 more
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Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Metformin is 1,1-dimethylbiguanide hydrochloride, is the first-line therapy for type 2 diabetes. Additionally, several studies focused on the role of metformin in antioxidant activities for the treatment of hepatic disorders. The experimentally
Intesar Tarik Numan +2 more
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The simultaneous effect of valproic acid and gamma radiation on telomerase activity and bax and Bcl-2 protein levels in MCF-7 breast cancer cell line [PDF]
, 2015 Background: Breast cancer is one of the most prevalent types of cancer. Factors such as ionizing radiation and chemotherapeutic agents can trigger apoptosis and cancer cell death.
Asadi, J. +3 more
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Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]
, 2016 Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo +6 more
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Severe Valproic Acid Intoxication Responding to Hemodialysis
Journal of Pediatric Emergency and Intensive Care Medicine, 2017 Valproic acid is a commonly used antiepileptic drug which causes intoxication easily due to its narrow therapeutic window. Here, we present a child with valproic acid poisoning who responded to hemodialysis.
Ali Ertuğ Arslanköylü +4 more
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New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin +8 more
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Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure [PDF]
, 2017 Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood.
Hurley, Joyce Harts +4 more
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Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children
MCBS (Molecular and Cellular Biomedical Sciences), 2019 Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand.
I Gusti Ngurah Made Suwarba +3 more
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Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
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