Results 21 to 30 of about 34,671 (226)
Frontiers in Cell and Developmental Biology, 2022 Neuroinflammation is a critical and targetable pathogenic component of neurodegenerative diseases, including glaucoma, the leading cause of irreversible blindness.
James R. Tribble +5 more
doaj +1 more source
Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested.
Mohammad Shokrzadeh +4 more
doaj
Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice [PDF]
International Neurourology Journal, 2021 Purpose Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and ...
Sang-Seo Park +4 more
doaj +1 more source
Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Case Reports in Psychiatry, 2014 Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event.
Jennifer D. Twilla, Andrew S. Pierce
doaj +1 more source
Impact of enriched environment on retinal thickness in zebrafish exposed to valproic acid [PDF]
Revista Brasileira de OftalmologiaObjective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders.
Mariana Aguirre-Rebolledo +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Advanced Science, EarlyView.This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia +6 more
wiley +1 more source
Evaluation of Antitumor Activity of Valproic Acid on K562 cells: In Vitro [PDF]
Journal of Fasa University of Medical Sciences, 2016 Backgrond & Objective: This study was performed to evaluate the antitumor effects of valproic acid (VPA) drug on K562 cells in vitro. Material & Methods: For this purpose, K562 cells were cultured and treated with different doses of valproic acid, and ...
Shahin Aalaei Diman +2 more
doaj +1 more source
Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic –Clonic Seizures in Adults – A Randomized Controlled Trial [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients.
VISHAL PRAKASH GIRI +5 more
doaj +1 more source
Growing use of valproic acid in substance use disorders
European Psychiatry, 2022 Introduction Valproic acid is an antiepileptic drug used in different fields of Psychiatry. It is known mostly for its use in managing patients with bipolar affective disorder.
J. Romão +5 more
doaj +1 more source