Serum concentrations of valproic acid in people with epilepsy: Clinical implication [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Therapeutic drug monitoring (TDM) allows personalizing the dose of valproic acid in patients with epilepsy to optimize drug therapy, minimize adverse effects and detect interactions.
Angel T. Alvarado +12 more
doaj +1 more source
Valproic acid-induced hyperammonemic encephalopathy: a clinical case
European Psychiatry, 2022 Introduction Valproic acid is a psychotropic drug used for several years, due to its properties as a mood stabilizer, being considered as first-line treatment for bipolar disorder.
M. Felizardo, C. Freitas
doaj +1 more source
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo [PDF]
, 2013 Targeted drugs have significantly improved the therapeutic options for advanced renal cell carcinoma (RCC). However, resistance often develops, negating the benefit of these agents.
Bartsch, Georg +6 more
core +10 more sources
A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism
Developmental Neuroscience, 2020 Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment.
D. Chaliha +6 more
semanticscholar +1 more source
Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Metformin is 1,1-dimethylbiguanide hydrochloride, is the first-line therapy for type 2 diabetes. Additionally, several studies focused on the role of metformin in antioxidant activities for the treatment of hepatic disorders. The experimentally
Intesar Tarik Numan +2 more
doaj +1 more source
Microsystems & Nanoengineering, 2020 Prenatal exposure to environmental insults can increase the risk of developing neurodevelopmental disorders. Administration of the antiepileptic drug valproic acid (VPA) during pregnancy is tightly associated with a high risk of neurological disorders in
Kangli Cui +10 more
semanticscholar +1 more source
The simultaneous effect of valproic acid and gamma radiation on telomerase activity and bax and Bcl-2 protein levels in MCF-7 breast cancer cell line [PDF]
, 2015 Background: Breast cancer is one of the most prevalent types of cancer. Factors such as ionizing radiation and chemotherapeutic agents can trigger apoptosis and cancer cell death.
Asadi, J. +3 more
core +1 more source
Severe Valproic Acid Intoxication Responding to Hemodialysis
Journal of Pediatric Emergency and Intensive Care Medicine, 2017 Valproic acid is a commonly used antiepileptic drug which causes intoxication easily due to its narrow therapeutic window. Here, we present a child with valproic acid poisoning who responded to hemodialysis.
Ali Ertuğ Arslanköylü +4 more
doaj +1 more source
Obeticholic Acid Ameliorates Valproic Acid–Induced Hepatic Steatosis and Oxidative Stress
Molecular Pharmacology, 2020 Farnesoid X receptor (FXR), or NR1H4, protects the liver from insults of various etiologies. A role of FXR in drug-induced liver injury has also been hypothesized yet only marginally investigated.
Z. Gai +4 more
semanticscholar +1 more source
Sudden valproate-induced hyperammonemia managed with L-carnitine in a medically healthy bipolar patient: Essential review of the literature and case report [PDF]
, 2017 Valproic Acid is a commonly used psychiatric drug primarily used as a mood stabilizer. Mild hyperammonemia is a Valproic Acid common adverse effect.
Ballabio, Matteo +5 more
core +1 more source