Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice [PDF]
International Neurourology Journal, 2021 Purpose Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and ...
Sang-Seo Park +4 more
doaj +1 more source
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. [PDF]
, 2020 Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor. Recently, we developed a patient-derived orthotopic xenograft (PDOX) model of adult pleomorphic RMS.
Dry, Sarah M +16 more
core
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
, 2010 Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
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Italian Wikipedia and epilepsy: an infodemiological study of online information-seeking behavior [PDF]
, 2018 Wikipedia is the most commonly accessed source of health information by both healthcare professionals and the lay public worldwide. We aimed to evaluate information-seeking behavior of Internet users searching the Italian Wikipedia for articles related ...
Bragazzi, Nicola Luigi +8 more
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Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]
, 2017 Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC +9 more
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Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction
Case Reports in Psychiatry, 2014 Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event.
Jennifer D. Twilla, Andrew S. Pierce
doaj +1 more source
Impact of enriched environment on retinal thickness in zebrafish exposed to valproic acid [PDF]
Revista Brasileira de OftalmologiaObjective: Embryonic exposure to valproic acid is a widely used model for the study of neurodevelopmental disorders such as autism spectrum disorders.
Mariana Aguirre-Rebolledo +4 more
doaj +1 more source
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]
, 2008 Cigarette smoke (CS)–induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David +4 more
core +2 more sources
Evaluation of Antitumor Activity of Valproic Acid on K562 cells: In Vitro [PDF]
Journal of Fasa University of Medical Sciences, 2016 Backgrond & Objective: This study was performed to evaluate the antitumor effects of valproic acid (VPA) drug on K562 cells in vitro. Material & Methods: For this purpose, K562 cells were cultured and treated with different doses of valproic acid, and ...
Shahin Aalaei Diman +2 more
doaj +1 more source