Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line [PDF]
, 2000 The biochemical mechanisms mediating the rapid distribution of valproic acid across placenta are not precisely known. We have characterized valproic acid transport by the human trophoblast using the human choriocarcinoma cell line, BeWo.
Audus, Kenneth L., Utoguchi, Naoki
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The effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural study [PDF]
, 2013 This study was undertaken to investigate the effect of valproic acid and protective effects of vitamin E and folic acid on rat ovary ultrastructural changes. Twenty-four Wistar rats were used. Animals were divided into four groups.
Akkus, Murat +2 more
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Valproic Acid-Associated Acute Pancreatitis: Systematic Literature Review. [PDF]
, 2023 Long-term medication with valproic acid has been associated with acute pancreatitis. The purpose of this report is to gain insight into the features of this pancreatitis.
Bianchetti, M.G. +7 more
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Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]
, 2016 Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo +6 more
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Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children
MCBS (Molecular and Cellular Biomedical Sciences), 2019 Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand.
I Gusti Ngurah Made Suwarba +3 more
doaj +1 more source
Maternal Swimming Exercise During Pregnancy Improves Memory Through Enhancing Neurogenesis and Suppressing Apoptosis via Wnt/β-Catenin Pathway in Autistic Mice [PDF]
International Neurourology Journal, 2021 Purpose Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and ...
Sang-Seo Park +4 more
doaj +1 more source
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
Atmaca, Akin +8 more
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Clinical and Translational Science, 2023 Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods.
Toshihiko Yoshioka +13 more
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Fatal Hyperammonemic Brain Injury from Valproic Acid Exposure [PDF]
, 2012 Background: Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury.
Bega, Danny +4 more
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Frontiers in Cell and Developmental Biology, 2022 Neuroinflammation is a critical and targetable pathogenic component of neurodegenerative diseases, including glaucoma, the leading cause of irreversible blindness.
James R. Tribble +5 more
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