In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System [PDF]
, 2002 Background/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure.
Bellomo, Rinaldo +10 more
core +1 more source
Rescue strategies for valproic acid overdose poisoning: Case series and literature review [PDF]
, 2023 Renzhu Liu +4 more
openalex +1 more source
Developmental Dynamics, EarlyView.Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore +7 more
wiley +1 more source
Epigenetic treatment of solid tumours. A review of clinical trials [PDF]
, 2015 Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observe in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere
CODACCI PISANELLI, Giovanni +2 more
core +2 more sources
Resolution of generalized tonic seizures following focal ablative or resective surgery
Epileptic Disorders, EarlyView.Abstract Objective Focal brain lesions may underlie generalized tonic seizures, as seen in Lennox–Gastaut syndrome, by engaging bilateral neural networks. However, this seizure type is often not considered surgically remediable. Here, we describe the resolution of apparent electroclinically classic generalized tonic seizures in children originating ...
Sem L. Kampman +3 more
wiley +1 more source
Epileptic Disorders, EarlyView.Abstract Objective To summarize the electro‐clinical and genetic characteristics of children with Mowat–Wilson syndrome (MWS). Methods This study is a hospital‐based case series analyzing clinical data from 31 pediatric patients with MWS and epilepsy treated at Peking University First Hospital between June 2020 and December 2024.
Yi Ju, Tao‐yun Ji
wiley +1 more source
The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]
, 2019 © 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania +5 more
core +2 more sources
Valproic Acid Affects Neuronal Specification and Differentiation During Early Optic Tectum Development of Zebrafish [PDF]
, 2022 Sierra C. Dixon +7 more
openalex +1 more source
"ALTERED PLASMA ZINC LEVEL CONTRIBUTES TO THE DEVELOPMENTAL TOXICITY OF VALPROIC ACID IN SKELETAL SYSTEM OF RAT" [PDF]
Acta Medica Iranica, 2004 Valproic acid is one of the main antiepileptic drugs. There is an increased risk of neural tube defects and axial skeletal malformations among infants born to women who had received valproic acid.
M.Akbari1 +5 more
doaj +1 more source
Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid [PDF]
, 2015 BackgroundThe molecular mechanisms underlying autistic behaviors remain to be elucidated. Mutations in genes linked to autism adversely affect molecules regulating dendritic spine formation, function and plasticity, and some increase the mammalian target
Bernadeta Michalski +4 more
core +1 more source