Results 71 to 80 of about 74,623 (302)

Sex‐specific elevated incidence of glaucoma associated with topiramate versus valproate or lamotrigine in epilepsy, not migraine: A population‐based cohort study

Epilepsia, EarlyView.
Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei, Rachel Yui Ki Chu, Rachel Lancey Lai, Florinda Hui‐Ning Chu, Ian Yu Hin Leung, William Chun Yin Leung, Franco Wing Tak Cheng, Thomas Chi Ho Lam, Ian Chi Kei Wong, Esther Wai Yin Chan, Francisco Tsz Tsun Lai   +10 more
wiley   +1 more source

Freedon study: Real‐life outcomes of cenobamate in different lines of treatment

Epilepsia, EarlyView.
Abstract Objectives Cenobamate is an antiseizure medication (ASM) with proven effectiveness in individuals with highly refractory epilepsy. This study investigated the effectiveness and tolerability of cenobamate in different treatment lines and a less refractory setting. Methods This was a multicenter, retrospective, observational study.
Vicente Villanueva, José María Serratosa, Alejandro Fernández‐Cabrera, Manuel Toledo, Beatriz González‐Giráldez, José C. Estevez, Juan Jesús Rodríguez Uranga, Maria Machio Castelló, Maria Dolores Castro‐Vilanova, Juan José Poza, Xiana Rodríguez‐Osorio, Kevin G. Hampel, Elena Fonseca, Francisco Javier López‐González, Mercedes Garcés, Laura Abraira, Jordi Ciurans, Daniel Campos‐Fernández, Estevo Santamarina, Juan María Sanchez‐Caro, Lucas Iacampo, Julia Renau, Miguel Ángel García‐Quesada, Carla Anciones, María Isabel Chamorro, Iratxe Maestro, Pablo Cabezudo, Raquel Calle, Jesús Macarron, Beatriz Cabezas, María Carrasco, María López, Marta Marín, Rosa Querol, Belén Baena, Vanessa García‐Morales, Samuel López‐Maza, Álvaro Juiz, Blanca Mercedes‐Alvarez, Carla Amarante, Ana del Villar, Ascensión Castillo, Marta Rubio‐Roy, Javier Martinez‐Poles, Asier Gómez‐Ibáñez, Beatriz Parejo‐Carbonell, Anabelén Martínez Garcia, Ignacio Carrera, Pablo Iriarte, Fátima Romero‐Aguilera, on behalf of the Pharmacological Therapy Working group of the Spanish Epilepsy Society and Freedon Group   +50 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy

Journal of Pharmacological Sciences, 2018
Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effects of
Naoto Iizuka, Akane Morita, Chihiro Kawano, Asami Mori, Kenji Sakamoto, Masakazu Kuroyama, Kunio Ishii, Tsutomu Nakahara   +7 more
doaj   +1 more source

High Blood Ammonia Levels Associated with Long-term Valproic Acids Therapy in Epileptic Children

MCBS (Molecular and Cellular Biomedical Sciences), 2020
Background: Valproic acid is an effective drug for controlling seizure in children with epilepsy and it is usually used for treatment as long as two years or more.
I Gusti Lanang Sidiartha, I Gusti Ngurah Made Suwarba, Dyah Kanya Wati, Ida Bagus Subanada   +3 more
doaj   +1 more source

The correlation between telomerase activity and BaX/BcL-2 ratio in valproic acid-treated MCF-7 breast cancer cell line [PDF]

, 2015
Objective(s): Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms.
Asadi, J., Gharaei, R., Vafaiyan, Z.
core   +2 more sources

Human small cell lung cancer cell line (NCI-H146) tumor behaviour on the chicken embryo chorioallantoic membrane after the sodium valproate treatment [PDF]

, 2017
Small cell lung cancer (SCLC) is an aggressive form of cancer with 5-year survival rate and poor prognosis. Since patients' initial response to therapy is rapidly followed by a relapse with the drug-resistant disease, new therapies are required.
Balnytė, Ingrida, Mozūraitė, Raminta, Valančiūtė, Angelija, Vosyliūtė, Ruta, Šlekienė, Lina   +4 more
core   +2 more sources

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia

Saudi Pharmaceutical Journal, 2020
Epilepsy is a common neurologic disorder, which is efficiently treated with carbamazepine and valproic acid. Moreover, Saudi Ministry of Health implemented a new E-system for Poison Control Centers called Awtar to enhance technology utilization in ...
Reem S Al-Balawi, Mohammed A Alshehri, Abdullah S Alatawi, Abdullah M Al Shehri, Manal A Alshehry, Mohammed M.H. Al-Gayyar   +5 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source