Results 71 to 80 of about 34,671 (226)

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Decrease in the effectiveness of valproic acid against the background of antibacterial therapy with imipenem/cilastatin in pediatric practice: A case report

Сибирский научный медицинский журнал
A clinical case of the co-medication of valproic acid and cilastatin/imipenem in a 17-year-old girl with generalized tonic-clonic seizures is described.
A. B. Strok, M. S. Chenkurov, M. N. Kostyleva, D. A. Umutkuzina   +3 more
doaj   +1 more source

Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability

Epilepsia Open, EarlyView.
Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola, Alice Muda, Lucio Giordano, Renzo Guerrini, Alessandra Boncristiano, Nicola Pietrafusa, Maria Polselli, Francesca Bisulli, Francesca Ragona, Antonella Riva, Pasquale Striano, Domenica Immacolata Battaglia, Federico Vigevano   +12 more
wiley   +1 more source

Unveiling Thrombocytopenia Trends In Pediatric Epilepsy: The Valproate Connection

Journal of Rawalpindi Medical College
Objective: To determine the frequency and association of thrombocytopenia in patients on valproate therapy in the Pediatrics department of Pakistan Atomic Energy Hospital, Islamabad.
Kiran Nayab, Qurrat ul Ain, Ayesha Tariq, Israr Liaqat, Samra Javed, Nadia Mumtaz   +5 more
doaj   +1 more source

Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open‐label prospective study

Epilepsia Open, EarlyView.
Abstract Objective CDKL5 deficiency disorder (CDD) is an early‐onset developmental and epileptic encephalopathy characterized by frequent drug‐resistant seizures, cerebral visual impairment, motor dysfunction, and sleep and gastrointestinal disturbances.
Marco Perulli, Alessia De Gioia, Federica Ruggiero, Federica Ascione, Chiara Porto, Elisa Musto, Valentina Massaroni, Maria Picilli, Maria Luigia Gambardella, Michela Quintiliani, Ilaria Contaldo, Chiara Veredice, Domenica Immacolata Battaglia   +12 more
wiley   +1 more source

Cognitive safety under epicranial cortex stimulation of the epileptic focus

Epilepsia Open, EarlyView.
Abstract Epicranial focal cortex stimulation (FCS) is a new CE‐certified treatment for pharmacoresistant focal epilepsy. In a multicenter observational trial, we report cognitive tolerability in 11 patients with pharmacoresistant epilepsy undergoing epicranial focal cortex stimulation (eFCS) over the predominant seizure focus (left temporal (N = 4 ...
Kathrin Wagner, Iris Gorny, Julia Kustermann, Jessika Paula Losacker, Birgitta Metternich, Julia Berg, Bastian E. A. Sajonz, Volker Arnd Coenen, Elisabeth Kaufmann, Susanne Knake, Andreas Schulze‐Bonhage   +10 more
wiley   +1 more source

Betaine reduces valproic acid-induced hepatotoxicity [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Antiepileptic drugs  cause a wide range of side effects in patients, including hepatotoxicity particularly associated with valproic acid.
Amin Hasanvand, Parian Mahmoudi, Ali Rashidiani-Rashidabadi, Mohsen Mohammadi, Alimohammad Maleki, Sirous Jafari Zafarabadi, Hamidreza Mohammadi   +6 more
doaj  

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, EarlyView.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Levetiracetam and Valproic Acid: Effects on the Liver Functions and Ammonia Level in Children

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014
Purpose: There is evidence that levetiracetam and valproic acid causes a changes of serum ammonia level and liver function tests. The aim of this study was to evaluate the liver function parameters and ammonia level in children with seizures on treatment
Faruk Incecik, M. Ozlem Herguner, Sakir Altunbasak   +2 more
doaj