Results 91 to 100 of about 1,861,130 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The co-evolution of organizational value capture, value creation and sustainable advantage [PDF]

open access: yes
Despite recent emphasis on intra-organizational issues, scholarship on organizations, management and strategy remains unduly reliant on economic models, such as the industrial organization (IO) market structure-based analysis. The focus of such models is
Pitelis, Christos
core   +1 more source

Towards a co-creation framework in the retail banking services industry: a cross-cultural analysis [PDF]

open access: yes, 2017
An underlying theme in modern marketing is the notion that value is not solely created within the boundaries of the firm, it is created co-jointly with outside parties.
Cambra-Fierro, Jesús   +3 more
core  

How context shapes value co-creation: Spectator experience of sport events [PDF]

open access: yes, 2016
This paper applies the perspective of service-dominant logic, specifically value co-creation in service ecosystems to the context of sports. It builds on the notion that co-created value can only be understood as value-in-context. Therefore, a structural
Horbel, C   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

ウェルビーイング志向の価値共創とその分析視点 [PDF]

open access: yes, 2018
The purpose of this paper is to propose viewpoints for analysing well-being oriented value co-creation. We firstly explain the concept of transformative service research: TSR which centres on consumer well-being in service and discuss its importance in ...
ホー, バック, 白肌, 邦生
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Exploring value co-creation within networks : actor-to-actor service provision within a public transport service system [PDF]

open access: yes, 2011
Purpose: This study explores how value co-creation occurs at a network level in a service system comprising representatives of business, consumer, and community actors.
Alexander, Matthew, Jaakkola, Elina
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Exploring factors that influence customer engagement in value co-creation in higher education institutions using online platforms [PDF]

open access: yes, 2016
Higher Education Institutions (HEIs) can be described as a container that encompasses strong knowledgeable minds and experienced individuals. It is one of the service sectors comprised of a huge number of individuals who are attached for life with Higher
Hasan, N., Rahman, A. A.
core  

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