Results 151 to 160 of about 1,861,130 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

From Social Media Content to Value Co-Creation: Role of Environmental Attitude, Environmental Knowledge, and Green Truth. [PDF]

Foods
Usiña-Báscones G, Carrión-Bósquez N, Samaniego-Arias M, Marchena-Chanduvi R, Medina-Miranda S, Zambrano-Vélez W, Ruiz-García W, Llamo-Burga M, Ortiz-Regalado O.   +8 more
europepmc   +1 more source

Enabling Value Co-Creation in Healthcare through Blockchain Technology. [PDF]

Int J Environ Res Public Health, 2022
Russo-Spena T, Mele C, Cavacece Y, Ebraico S, Dantas C, Roseiro P, van Staalduinen W.   +6 more
europepmc   +1 more source

How collaborative innovation and co-creation can deliver value: a stakeholder approach [PDF]

This project explores how collaborative innovation and co-creation between stakeholders can deliver value for firms. In today’s increasingly competitive and fast-changing global marketplace, firms must seek to develop more frequent and higher quality ...
Clark, Moira, Dibley, Anne, Yenicioglu, Baskin   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The evolutionary game analysis of the decision-making behavior of live streaming stakeholders under the value co-creation. [PDF]

PLoS One, 2023
Jia S.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sensorial brand strategies for value co-creation [PDF]

Innovative Marketing, 2011
Clarinda Rodrigues, Bertil Hultén, Carlos Brito   +2 more
doaj   +1 more source

The impact of value co-creation behavior on customers' experiences with and loyalty to P2P accommodations. [PDF]

Front Psychol, 2022
Lyu J, Cao K, Yang S.
europepmc   +1 more source