Results 171 to 180 of about 201,185 (264)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Value Co-creation Mechanisms

open access: yes
A cocreation framework will be designed in this task and incrementally implemented in task T0102 in which all the IoT technology and applications stakeholders will be engaged to cocreate value taking increasingly active roles in the creation of value for ...
openaire   +1 more source

Ambiguity on Co-Creation of Value

open access: yesAmbiguity on Co-Creation of Value
本稿は,サービス・ドミナント・ロジック(SDL)における価値共創と,それ以前のイノベーション研究で取り上げられてきた製品開発過程における第三者参加による価値共創に言及し,両者の相違を明確にしている。イノベーション研究では,オープン・イノベーション,ユーザー・イノベーションの名の下で価値共創に言及されたが,近年はSDLにおけるそれとしばしば混同されることが多い。そのため,これらに参加した企業や個人属性の違いについても明確にした。その上でSDLにおける価値共創は,最終消費者が主体であり,製品開発過程だけではなく,消費・使用場面での価値共創をより重視していることを強調した。 This paper referred to co-creation of value that is often confused
openaire  

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

A service ecosystems perspective to explore social prescribing value co-creation for vulnerable young people in NEET situation. [PDF]

open access: yesBMC Health Serv Res
Farina I   +11 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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