Results 61 to 70 of about 4,889,999 (350)

Risk Analysis on Conceptual Design of Soekarno – Hatta International Airport Rail Link Project Using Value Engineering

open access: yesCSID Journal of Infrastructure Development, 2018
The Soekarno-Hatta International Airport Rail Link (SHIARL) project is arguably one of the best solutions to reduce uncertainty in travel time and to improve accessibility to and from Soekarno-Hatta International Airport.
Herawati Z. Rahman   +4 more
doaj   +1 more source

Mapping customer needs to engineering characteristics: an aerospace perspective for conceptual design

open access: yes, 2014
Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Bertoni, M.   +3 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Desain Prototipe Meja dan Kursi Pantai Portabel dengan Integrasi Pendekatan Ergonomi, Value Engineering dan Kansei Engineering

open access: yesJurnal Teknik Industri, 2012
This research highlighted a methodology to design prototype of portable dining table and chairs for the beach by the integration of Ergonomic, Value Engineering and Kansei Engineering. The case study of the research is on Kuwaru Beach. It has its special
Nora Yuanita Restantin   +2 more
doaj  

Value Engineering untuk Bangunan Gudang [PDF]

open access: yes, 2015
Value engineering sangat diperlukan dalam perencanaan proyek karena seringkali terdapat biaya yang tidak diperlukan terdapat dalam perencanaan proyek.
Paryati, N. (Ninik)
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Applying Information Gap Decision Theory for Uncertainty Management in Building Lifecycle Assessment

open access: yesBuildings
This study applies Info-Gap Decision Theory (IGDT) to manage uncertainties in early-stage lifecycle assessment (LCA) in the building sector, focusing on carbon emissions and cost optimization.
Tris Kee, Frankie Fu
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

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