Results 91 to 100 of about 3,582,587 (303)

The Contested Value of Life

Cambridge Quarterly of Healthcare Ethics
AbstractPutting a specific value on human life is important in many contexts and forms part of the basis for many political, administrative, commercial, and personal decisions. Sometimes, the value is set explicitly, sometimes even in monetary terms, but much more often, it is set implicitly through a decision that allows us to calculate the valuation ...
openaire   +2 more sources

Economic Value of Life in Iran: The Human Capital Approach. [PDF]

Iran J Public Health, 2021
Basakha M, Soleimanvandiazar N, Tavangar F, Daneshi S.   +3 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

‘Health Data Saves Lives’, But Which Lives?: The Non-Imagination of Ecological Peril in Precision Medicine

Medicine Anthropology Theory
Precision medicine is a field of future promise. Its imaginary is that ‘health data saves lives’. But which lives and at what costs? In this position piece, we direct attention to how non-imagination (Prainsack 2022) operates in the field of precision ...
Mette N. Svendsen, Olivia Spalletta
doaj   +1 more source

Estimates of the value of life lost from COVID-19 in Ohio. [PDF]

J Comp Eff Res, 2021
Mallow PJ.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

El milagro de seguir siendo

MedUNAB
Quizás la pregunta más antigua que el ser humano se ha formulado no es ¿de dónde venimos? ni ¿hacia dónde vamos?, sino una más íntima y más urgente, ¿Por qué permanezco?.
Stifer Yajaira Orduz-Soto
doaj   +1 more source

Application of discrete choice experiments to estimate value of life: a national study protocol in Iran. [PDF]

Cost Eff Resour Alloc, 2021
Mirzaee N, Takian A, Farzadfar F, Daroudi R, Kazemi Karyani A, Akbari Sari A.   +5 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source