Results 121 to 130 of about 5,028,257 (308)

Value’s of Mathematics Education and Citizenship Education [PDF]

open access: yes, 2011
Currently, the Indonesian plane of life is miserable, inparticular on behavior. It is shown by the mushrooming acts of corruption, bribery, anarchy, public deceiving, traffic incompliance, etc. This mean any problem in nation character.
Hardi , Suyitno
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Adjusting for cultural effects on countries’ education policy efficiency:an application of conditional full frontiers measures [PDF]

open access: yes
In this paper using Data Envelopment Analysis (DEA) we evaluate the influence of national culture on education policy efficiency for 20 OECD countries.
Halkos, George, Tzeremes, Nickolaos
core   +1 more source

Integrating on-line learning technologies into higher education [PDF]

open access: yes, 2004
This dissertation presents an in-depth, qualitative case study that documents the efforts of two UK universities to integrate on-line learning technologies into their teaching practices and course design.
Darking, Mary
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Review of Therapeutic Education: Working Alongside Troubled and Troublesome Children (Book Review) [PDF]

open access: yes, 2008
Therapeutic education requires a move from “a punitive, blame-based, unfairly competitive and deviant-defined culture” to “one that celebrates diversity and cultural differences” (p.11), from a deficit model of SEN and deviant model of challenging ...
Bigger, Stephen
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

TEACHER EDUCATION AND TEACHING PROFESSION VALUES IN INDONESIA AND IN THE US [PDF]

open access: yes
Education functions not only to transmit knowledge from teachers as educators to students as subjects of learning, but also to instill norms and moral values so that students may behave accordingly in the society.
Nurakhir, Asih
core  

Home - About - Disclaimer - Privacy