Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]
, 2015 Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa +6 more
core +2 more sources
Calcineurin/NFAT signaling represses genes Vamp1 and Vamp2 via PMCA-dependent mechanism during dopamine secretion by Pheochromocytoma cells. [PDF]
PLoS ONE, 2014 BACKGROUND:Plasma membrane Ca(2+)-ATPases (PMCA) extrude Ca(2+) ions out of the cell and contribute to generation of calcium oscillations. Calcium signaling is crucial for transcriptional regulation of dopamine secretion by neuroendocrine PC12 cells. Low
Michalina Kosiorek +3 more
doaj +1 more source
Biomolecules, 2023 Clinical data implicate fluctuations of high levels of plasma glucose in cardiovascular diseases. Endothelial cells (EC) are the first cells of the vessel wall exposed to them.
Laura Toma +5 more
doaj +1 more source
Alzheimer’s Research & Therapy, 2021 Background There is an urgent need for objective markers of Alzheimer’s disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying therapies ...
Alberto Lleó +21 more
doaj +1 more source
Kernel methods for detecting coherent structures in dynamical data
, 2019 We illustrate relationships between classical kernel-based dimensionality reduction techniques and eigendecompositions of empirical estimates of reproducing kernel Hilbert space (RKHS) operators associated with dynamical systems.
Husic, Brooke E. +3 more
core +1 more source
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
, 2016 Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E +7 more
core +1 more source
Shock Pulse Shaping in a Small-Form Factor Velocity Amplifier
Shock and Vibration, 2010 This theme of this paper is the design and characterisation of a velocity amplifier (VAMP) machine for high-acceleration shock testing of micro-scale devices.
Gerard Kelly +3 more
doaj +1 more source
Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.
PLoS ONE, 2013 CALM (clathrin assembly lymphoid myeloid leukemia protein) is a cargo-selective adaptor for the post-Golgi R-SNAREs VAMPs 2, 3, and 8, and it also regulates the size of clathrin-coated pits and vesicles at the plasma membrane.
Daniela A Sahlender +4 more
doaj +1 more source
Virtual Integration Platforms (VIP) –A Concept for Integrated and Interdisciplinary Air Transportation Research and Assessment [PDF]
, 2011 The paper descibes a new methodology for a holistic development of air transportation concepts. The Virtual Integration Plattform (VIP) concept is based on an IT tool chain as well as human collaborative methods to deal with complex systems.
Gollnick, Volker +3 more
core +1 more source
Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source