Results 41 to 50 of about 6,778 (229)

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang, Jiahe Wang, Ziyu Diao, Xin Tan, Shijun Qiu, Jie An   +5 more
wiley   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

VAMP-Based Kalman Filtering Under Non-Gaussian Process Noise

IEEE Open Journal of Signal Processing
Estimating time-varying signals becomes particularly challenging in the face of non-Gaussian (e.g., sparse) and/or rapidly time-varying process noise.
Tiancheng Gao, Mohamed Akrout, Faouzi Bellili, Amine Mezghani   +3 more
doaj   +1 more source

Amyloid‐β–Related Cortical Susceptibility Alterations in Individuals Under Assessment for Alzheimer's Disease: A χ‐Separation Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Assessment of amyloid‐β (Aβ) burden and associated iron deposition and neurodegeneration is important for Alzheimer's disease (AD) management. Although quantitative susceptibility mapping (QSM) detects iron and myelin changes, conventional metrics suffer from signal cancelation between paramagnetic and diamagnetic components ...
Hiroyuki Tatekawa, Tatsushi Oura, Akitoshi Takeda, Ayako Omori, Natsuko Atsukawa, Shu Matsushita, Daisuke Horiuchi, Hirotaka Takita, Yasuhito Mitsuyama, Yoshihito Ban, Taro Shimono, Josef Pfeuffer, Daiju Ueda, Yoshiaki Itoh, Yukio Miki   +14 more
wiley   +1 more source

Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells

Cells, 2018
Synaptic vesicle fusion is mediated by an assembly of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs), composed of syntaxin 1, soluble NSF-attachment protein (SNAP)-25, and synaptobrevin-2/VAMP-2.
Can Wang, Zhuo Ma, Dong-Ying Yan, Chang Liu, Yu Deng, Wei Liu, Zhao-Fa Xu, Bin Xu   +7 more
doaj   +1 more source

Are All “Good” Employees Susceptible to Moral Biases? Exceptional (Versus Intermediate) Moral Character Shapes Resilience to Daily “DIAMONDS” Situations That Trigger Moral Disengagement

Journal of Organizational Behavior, EarlyView.
ABSTRACT The non‐rationalist view of morality holds that all employees—including “good” apples—are liable to do bad because they are susceptible to moral biases in everyday situational encounters. In contrast, the rationalist or trait view suggests that employees with strong moral character should be resilient against moral biases across situations and
Babatunde Ogunfowora, Varun Sharma, Mohammad Khalilinejad, Kimberly Weston Moore   +3 more
wiley   +1 more source

Multi‐Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT PurposeTo implement and evaluate chemical exchange saturation transfer (CEST) at ultra‐high field on a whole‐body 11.7 T scanner using parallel transmission (pTx). MethodsTailored pTx CEST saturation pulses were optimized to achieve a spatially uniform target B1+ while satisfying SAR and power constraints either defined by conservatively ...
Camélia Ressam, Joseph Brégeat, Alfredo L. Lopez Kolkovsky, Alexis Amadon, Alexandre Vignaud, Aurélien Massire, Son Chu, Shajan Gunamony, Nicolas Boulant, Vincent Gras, Franck Mauconduit, Luisa Ciobanu   +11 more
wiley   +1 more source

A Generalized Approach to Solving Deep Learning‐Based Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (QSM + qBOLD or QQ) for Oxygen Extraction Fraction (OEF) Mapping Across Diverse Acquisition Schemes

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose QQ, a recently proposed oxygen extraction fraction (OEF) mapping technique combining quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent (qBOLD) (QSM + qBOLD = QQ), generates OEF maps noninvasively from a single routine MRI sequence, without requiring vascular challenges used in other OEF approaches.
Tian Qiu, Ada Ally, Arpita Misra, Gloria C. Chiang, Thanh D. Nguyen, Susan A. Gauthier, Shun Zhang, Yi Wang, Junghun Cho   +8 more
wiley   +1 more source

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications

PM&R, EarlyView.
Abstract Background Hypovitaminosis D is associated with adverse health outcomes, including increased mortality in patients with cancer. Although vitamin D insufficiency (23%–72%) and deficiency (20%–71%) are common among patients admitted to inpatient rehabilitation, their prevalence and predictors in cancer‐specific inpatient rehabilitation ...
Jegy M. Tennison, Minxing Chen, Areeba Hafeez, Ananya Krishnan, Sefia Khan, Rony Dev, Sonal Admane, Eduardo Bruera   +7 more
wiley   +1 more source