Results 91 to 100 of about 138,627 (294)

Antibacterial Essential Oils as Adjuvants to Inhibit Antibiotic Resistance in Multidrug‐resistant Bacteria

open access: yesChemistry &Biodiversity, EarlyView.
Combining bacterially inactivated antibiotics with antibacterial essential oils (EOs) is an alternative combinatorial therapy against antibiotic‐resistant bacteria, as EOs can also modulate resistance. Apart from the rehabilitation of the antibiotic, this combination is probably more difficult to overcome evolutionarily due to the antibacterial mixture
Rafael Torres‐Martínez   +5 more
wiley   +1 more source

Efficacy of Essential Oil of Algrizea minor Sobral, Faria & Proença (Myrtaceae) in Combating Methicillin‐resistant Staphylococcus aureus: Antibacterial and Virulence Modulation Studies Conducted In Vitro and In Vivo

open access: yesChemistry &Biodiversity, EarlyView.
This study explored the antibacterial, antivirulence, and in vivo effects of Algrizea minor essential oil (EOAM), against MRSA isolates. Chemical analysis by GC‐MS has been performed. The oil exhibited synergistic effects when combined with amoxicillin and oxacillin, inhibiting biofilm formation and reducing S. aureus‐induced hemolysis.
Amanda Vieira de Barros   +14 more
wiley   +1 more source

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus Aureus by Coordination to Rhenium Carbonyl Complexes

open access: yesChemBioChem, EarlyView.
Coordination of antifungal azoles to rhenium di‐ and tricarbonyl complexes results in compounds with enhanced antimicrobial efficacy—up to 32‐fold minimum inhibitory concentration improvement—against methicillin‐sensitive and methicillin‐resistant Staphylococcus aureus over parent azoles.
Kevin Schindler   +12 more
wiley   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

open access: yesChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia   +4 more
wiley   +1 more source

Vancomycin Removal During High-Volume Peritoneal Dialysis in Acute Kidney Injury Patients: A Prospective Cohort Clinical Study

open access: yesKidney International Reports, 2019
Introduction: Vancomycin pharmacokinetic data in patients with acute kidney injury (AKI) on high-volume peritoneal dialysis (HVPD) are lacking. The aims were to study the pharmacokinetics of i.v.
Daniela Ponce   +4 more
doaj  

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin   +19 more
wiley   +1 more source

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