Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
Microorganisms, 2021 Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE.
Alexandra A. Guffey, Patrick J. Loll
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Controlling the Evolution of Selective Vancomycin Resistance through Successful Ophthalmic Eye-Drop Preparation of Vancomycin-Loaded Nanoliposomes Using the Active-Loading Method [PDF]
Pharmaceutics, 2023 Vancomycin is the front-line defense and drug of choice for the most serious and life-threatening methicillin-resistant Staphylococcus aureus (MRSA) infections.
El Tahra M. Ahmed +4 more
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A Genetic Locus in Elizabethkingia anophelis Associated with Elevated Vancomycin Resistance and Multiple Antibiotic Reduced Susceptibility [PDF]
AntibioticsThe Gram-negative Elizabethkingia express multiple antibiotic resistance and cause severe opportunistic infections. Vancomycin is commonly used to treat Gram-positive infections and has also been used to treat Elizabethkingia infections, even though Gram-
William L. Johnson +6 more
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Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance [PDF]
Microbiology Spectrum, 2022 Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Si Hyoung Park +5 more
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Risk factors for vancomycin resistance in patients with Enterococcus faecium bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort [PDF]
Microbiology SpectrumEnterococcus faecium is difficult to treat owing to its intrinsic and acquired resistance to antibiotics, particularly vancomycin. Vancomycin-resistant Enterococcus faecium is an important cause of bloodstream infections in healthcare settings with ...
Laura Wagner +15 more
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Vancomycin Resistance in Enterococcus faecium from the Dallas, Texas, Area Is Conferred Predominantly on pRUM-Like Plasmids [PDF]
mSphere, 2023 Vancomycin-resistant E. faecium (VREfm) is a significant public health concern because of limited treatment options. Genomic surveillance can be used to monitor VREfm transmission and evolution.
Moutusee Islam +5 more
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Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits. [PDF]
PLoS BiologyClostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin.
Jessica E Buddle +8 more
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PLoS PathogensVancomycin has proven remarkably durable to resistance evolution by Staphylococcus aureus despite widespread treatment with vancomycin in the clinic. Only 16 cases of vancomycin-resistant S. aureus (VRSA) have been documented in the United States.
Samuel E Blechman, Erik S Wright
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Role of membrane vesicles in the transmission of vancomycin resistance in Enterococcus faecium [PDF]
Scientific ReportsClonal transmission and horizontal gene transfer (HGT) contribute to the spread of vancomycin-resistant enterococci (VRE) in global healthcare. Our study investigated vesiduction, a HGT mechanism via membrane vesicles (MVs), for vanA and vanB genes that ...
Johanna Lehmkuhl +5 more
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Methicillin resistance Staphylococcus aureus (MRSA) and Vancomycin Resistant Staphylococcus aureus (VRSA) problem in human and livestock and solutions. [PDF]
Basrah Journal of Veterinary Research, 2023 Staphylococcus aureus is an opportunistic bacterium of humans and other mammals that is becoming more clinically and veterinary important due to its fast development of antibiotic resistance. Some of these S. aureus varieties are methicillin-resistant S.
Marwan Mohammed +2 more
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