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Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance

Antibiotics, 2023
Vancomycin and daptomycin are first-line drugs for the treatment of complicated methicillin-resistant Staphylococcus aureus (MRSA) infections, including bacteremia.
Vladimir Gostev, Olga Kalinogorskaya, Julia Sopova, Ofelia Sulian, Polina Chulkova, Maria Velizhanina, Irina Tsvetkova, Irina Ageevets, Vladimir Ageevets, Sergey Sidorenko   +9 more
doaj   +2 more sources

The Association of the mazEF Toxin-antitoxin System and Vancomycin Resistance in Clinical Isolates of Vancomycin Resistant Enterococcus faecalis [PDF]

Journal of Pure and Applied Microbiology, 2022
Vancomycin resistant enterococci are challenging bacteria as they are difficult to be eradicated. Toxin-antitoxin (TA) systems are genetic elements located in most prokaryotic genomes.
Amira M. Sultan, Nawal S. Gouda
doaj   +2 more sources

Detection of Vancomycin Resistance among Enterococcus faecalis and Staphylococcus aureus [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Vancomycin remains the drug of choice for resistant gram positive infections caused by Enterococcus spp and Methicillin resistant Staphylococcus aureus (MRSA). Increased use of vancomycin has led to frank resistance and increase in MIC (
Ramya Rengaraj, Shanthi Mariappan, Uma Sekar, Arunagiri Kamalanadhan   +3 more
doaj   +1 more source

Utility of Minimum Inhibitory Concentration values and Antibiotyping for Epidemiological study of Vancomycin Resistant Enterococci in a Tertiary Care Hospital

Journal of Pure and Applied Microbiology, 2021
Vancomycin-resistant enterococci (VRE) have emerged as an important nosocomial infection. Three important vancomycin resistance types namely, VanA, VanB, VanC are very commonly found in enterococci.
Deepa Devhare
doaj   +1 more source

Vancomycin resistant enterococci in urine cultures: Antibiotic susceptibility trends over a decade at a tertiary hospital in the United Kingdom [PDF]

Investigative and Clinical Urology, 2016
Purpose: Enterococci are a common cause of urinary tract infection and vancomycin-resistant strains are more difficult to treat. The purpose of this surveillance program was to assess the prevalence of and determine the risk factors for vancomycin ...
Liam Toner, Nathan Papa, Sani H. Aliyu, Harveer Dev, Nathan Lawrentschuk, Samih Al-Hayek   +5 more
doaj   +1 more source

Modulating activity of vancomycin and daptomycin on the expression of autolysis cell-wall turnover and membrane charge genes in hVISA and VISA strains. [PDF]

PLoS ONE, 2012
Glycopeptides are still the gold standard to treat MRSA (Methicillin Resistant Staphylococcus aureus) infections, but their widespread use has led to vancomycin-reduced susceptibility [heterogeneous Vancomycin-Intermediate-Staphylococcus aureus (hVISA ...
Viviana Cafiso, Taschia Bertuccio, Daniela Spina, Simona Purrello, Floriana Campanile, Cinzia Di Pietro, Michele Purrello, Stefania Stefani   +7 more
doaj   +1 more source

New Mutations in cls Lead to Daptomycin Resistance in a Clinical Vancomycin- and Daptomycin-Resistant Enterococcus faecium Strain

Frontiers in Microbiology, 2022
Daptomycin (DAP), a last-resort antibiotic for treating Gram-positive bacterial infection, has been widely used in the treatment of vancomycin-resistant enterococci (VRE).
Weiwei Li, Weiwei Li, Jiamin Hu, Ling Li, Mengge Zhang, Qingyu Cui, Yanan Ma, Hainan Su, Xuhua Zhang, Hai Xu, Mingyu Wang   +10 more
doaj   +1 more source

Molecular Characterization of Methicillin Resistant and Extended Spectrum ?-Lactamase Staphylococcus aureus Isolated from Burn Patients

Kurdistan Journal of Applied Research, 2020
Antibiotic resistance has become a major world health challenge and has limited the ability of physician's treatment. Staphylococcus aureus the most notorious pathogens causes morbidity and mortality especially in burn patients.
Shawnm Ahmed Aziz
doaj   +3 more sources

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

Frontiers in Microbiology, 2018
Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic.
Nigam M. Mishra, Izabela Stolarzewicz, Izabela Stolarzewicz, David Cannaerts, Joris Schuermans, Rob Lavigne, Yannick Looz, Bart Landuyt, Liliane Schoofs, Dominique Schols, Jan Paeshuyse, Peter Hickenbotham, Martha Clokie, Walter Luyten, Walter Luyten, Erik V. Van der Eycken, Erik V. Van der Eycken, Yves Briers, Yves Briers   +18 more
doaj   +1 more source

Proficiency of Clinical Laboratories in and near Monterrey, Mexico, To Detect Vancomycin-Resistant Enterococci

Emerging Infectious Diseases, 1999
Early detection of vancomycin-resistant enterococci is important for preventing its spread among hospitalized patients. We surveyed the ability of eight hospital laboratories in and near Monterrey, Mexico, to detect vancomycin resistance in Enterococcus ...
L. Clifford McDonald, Luis R. Garza, William R. Jarvis   +2 more
doaj   +1 more source