Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
Microorganisms, 2021 Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE.
Patrick J Loll
exaly +3 more sources
Controlling the Evolution of Selective Vancomycin Resistance through Successful Ophthalmic Eye-Drop Preparation of Vancomycin-Loaded Nanoliposomes Using the Active-Loading Method. [PDF]
Pharmaceutics, 2023 Vancomycin is the front-line defense and drug of choice for the most serious and life-threatening methicillin-resistant Staphylococcus aureus (MRSA) infections.
Ahmed ETM +4 more
europepmc +2 more sources
A Genetic Locus in Elizabethkingia anophelis Associated with Elevated Vancomycin Resistance and Multiple Antibiotic Reduced Susceptibility. [PDF]
Antibiotics (Basel)The Gram-negative Elizabethkingia express multiple antibiotic resistance and cause severe opportunistic infections. Vancomycin is commonly used to treat Gram-positive infections and has also been used to treat Elizabethkingia infections, even though Gram-
Johnson WL +6 more
europepmc +2 more sources
Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance. [PDF]
Microbiol Spectr, 2022 Vancomycin and β-lactams are clinically important antibiotics that inhibit the formation of peptidoglycan cross-links, but their binding targets are different.
Park SH +5 more
europepmc +2 more sources
Risk factors for vancomycin resistance in patients with <i>Enterococcus faecium</i> bloodstream infections: an analysis of the Munich Multicentric Enterococci Cohort. [PDF]
Microbiol SpectrEnterococcus faecium is difficult to treat owing to its intrinsic and acquired resistance to antibiotics, particularly vancomycin. Vancomycin-resistant Enterococcus faecium is an important cause of bloodstream infections in healthcare settings with ...
Wagner L +15 more
europepmc +2 more sources
Vancomycin Resistance in Enterococcus faecium from the Dallas, Texas, Area Is Conferred Predominantly on pRUM-Like Plasmids. [PDF]
mSphere, 2023 Vancomycin-resistant E. faecium (VREfm) is a significant public health concern because of limited treatment options. Genomic surveillance can be used to monitor VREfm transmission and evolution.
Islam M +5 more
europepmc +2 more sources
Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes [PDF]
Microbiology SpectrumThe rise in antibiotic resistance limits the availability of antibiotics to treat bacterial infections. Despite this, antibiotic development pipelines remain sparse which makes using adjuvants to reverse antibiotic resistance a promising therapeutic ...
Zajeba Tabashsum +4 more
doaj +3 more sources
Emergence of vancomycin-resistant enterococci from vancomycin-susceptible enterococci in hospitalized patients under antimicrobial therapy [PDF]
Journal of Global Antimicrobial Resistance, 2023 : Objectives: Enterococci are opportunistic pathogens with plastic genomes that evolve, acquire, and transmit antimicrobial-resistant determinants such as vancomycin resistance clusters.
Jessin Janice +4 more
doaj +2 more sources
PLoS PathogensVancomycin has proven remarkably durable to resistance evolution by Staphylococcus aureus despite widespread treatment with vancomycin in the clinic. Only 16 cases of vancomycin-resistant S. aureus (VRSA) have been documented in the United States.
Erik Scott Wright, Samuel Blechman
exaly +2 more sources
Identification of pathways to high-level vancomycin resistance in Clostridioides difficile that incur high fitness costs in key pathogenicity traits. [PDF]
PLoS BiolClostridioides difficile is an important human pathogen, for which there are very limited treatment options, primarily the glycopeptide antibiotic vancomycin.
Buddle JE +8 more
europepmc +2 more sources