Results 171 to 180 of about 82,028 (251)

Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile. [PDF]

Mol Microbiol
Belitsky BR.
europepmc   +1 more source

Protein–Protein Interactions Between Peptidoglycan, Lipopolysaccharide, and Phospholipid Biosynthesis Enzymes in Escherichia coli

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
MurA, the first peptidoglycan biosynthesis enzyme, interacts with essential proteins involved in lipopolysaccharide and phospholipid biogenesis and is associated with the LapB interactome. Gram‐negative bacteria are protected by a three‐layered cell envelope and must tightly coordinate the biosynthesis of phospholipids (PL), peptidoglycan (PG) and ...
Lea‐Janina Tilg, Sophia Weber, Hannah Bille, Anna‐Maria Möller, Franz Narberhaus   +4 more
wiley   +1 more source

The Emergent Invasive Serotype 4 ST10172 Strain Acquires vanG-Type Vancomycin-Resistance Element: A Case of a 66-Year-Old With Bacteremic Pneumococcal Pneumonia. [PDF]

J Infect Dis
Chochua S, Beall B, Lin W, Tran T, Rivers J, Li Z, Arvay ML, Kobayashi M, Houston J, Arias S, McGee L.   +10 more
europepmc   +1 more source

Long‐Term Use of Rezafungin: A Case Report and Insights Into Real‐World Access

Transplant Infectious Disease, EarlyView.
Jian Mei Li, Jacqueline E. Clark, Tiffany Wu   +2 more
wiley   +1 more source

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo, Jemma Gullick, Ryan F. Leung, Alex J. Fulcher, Rachel W. Cass, Julien Tailhades, Anton Y. Peleg, Jennifer A. E. Payne, Meredith O’Keeffe, Max J. Cryle   +9 more
wiley   +1 more source

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source

Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall, Sam Tucker, Max J. Cryle, Julien Tailhades   +3 more
wiley   +1 more source