Results 191 to 200 of about 82,028 (251)

Olikomycin A Disrupts Gram‐Positive Bacterial Membranes Through Calcium‐Dependent Binding to Phosphatidylglycerol

open access: yesArchiv der Pharmazie, Volume 359, Issue 8, August 2026.
Olikomycin A, a calcium‐dependent lipopeptide antibiotic, targets Gram‐positive bacteria by binding to phosphatidylglycerol and rapidly disrupting membrane integrity. Unlike daptomycin, it induces extensive membrane remodeling, vesicle deformation, and fragmentation.
Luisa Munz   +4 more
wiley   +1 more source

Structural Modifications of Nonsteroidal Anti‐Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery

open access: yesArchiv der Pharmazie, Volume 359, Issue 8, August 2026.
This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan   +2 more
wiley   +1 more source

Autologous Cancellous Bone Interposition to Enhance Tendon‐Bone Integration in Hamstring Tendon Anterior Cruciate Ligament Reconstruction: A Surgical Technique

open access: yesArthroscopy Techniques, Volume 15, Issue 8, August 2026.
Abstract Hamstring tendon autografts remain a popular choice for anterior cruciate ligament reconstruction due to their favorable biomechanical properties and reduced donor‐site morbidity; however, delayed tendon‐to–bone integration and tunnel widening continue to limit outcomes when compared with bone–patellar tendon–bone grafts.
Cillian J. Keogh   +2 more
wiley   +1 more source

Mini‐Open Short Superficial and Deep Medial Collateral Ligament Reconstruction of the Knee With Adjustable System

open access: yesArthroscopy Techniques, Volume 15, Issue 8, August 2026.
Abstract Successful medial collateral ligament (MCL) reconstruction depends on multiple anatomical and biomechanical factors. Various techniques have been described, ranging from isolated superficial MCL reconstructions to complex combined medial reconstructions.
Pablo Gelber   +2 more
wiley   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga   +20 more
wiley   +1 more source

Collagen‐Based Regenerative Therapy in a Critical Ischemic Diabetic Foot Ulcer: A Limb‐Salvaging Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A 58‐year‐old man with diabetes, end‐stage renal disease, and severe peripheral arterial disease had a chronic ischemic foot ulcer refractory to one year of conventional therapy. Injectable collagen‐based regenerative therapy produced complete epithelialization within three months and durable limb salvage, even after a thermally induced ...
Ma'moun Qawasmeh   +4 more
wiley   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari   +2 more
wiley   +1 more source

Disseminated Chronic Tophaceous Gout With Multi‐Tissue Involvement

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Gout is a metabolic condition in which hyperuricaemia leads to deposition of monosodium urate (MSU) crystals in synovial and peri‐articular tissues. (1) Acutely, synovial deposition causes a painful inflammatory reaction. Over time, chronic hyperuricaemia can lead to deposition of uric acid crystals in alternate tissues, with granulomatous ...
Yee Leng Loh, Fiona Combe
wiley   +1 more source

Green Chiral HPLC Method for Lumefantrine Analysis: Method Development, Greenness Assessment, and Computational Studies

open access: yesChirality, Volume 38, Issue 8, August 2026.
A green chiral HPLC method was developed and validated for the determination of lumefantrine enantiomers. The method employs ethanol as a mobile phase as a sustainable and efficient alternative to hexane. The chiral recognition mechanism and elution order of the enantiomers were investigated using electronic circular dichroism and molecular docking ...
Amanda Mohr   +4 more
wiley   +1 more source

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