Estudos sobre o módulo toxina-antitoxina VapBC 1 de >i/i< sorovar Copenhageni [PDF]
, 2022 Deborah Kohn Damiano
semanticscholar +3 more sources
Crystal structure of proteolyzed VapBC and DNA‐bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+‐dependent ribonuclease [PDF]
The FASEB Journal, 2019 Bacterial toxin‐antitoxin (TA) system has gained attention for its essential roles in cellular maintenance and survival under harsh environmental conditions such as nutrient deficiency and antibiotic treatment.
Dong-won Park +7 more
semanticscholar +3 more sources
Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
Apoptosis like symptoms associated with abortive infection of Mycobacterium smegmatis by mycobacteriophage D29. [PDF]
PLoS ONE, 2022 Mycobacteriophages are phages that infect mycobacteria resulting in their killing. Although lysis is the primary mechanism by which mycobacteriophages cause cell death, others such as abortive infection may also be involved.
Fatema Calcuttawala +5 more
doaj +2 more sources
Journal of Molecular Biology, 2011 Toxin-antitoxin (TA) loci are common in archaea and prokaryotes and allow cells to rapidly adapt to changing environmental conditions through release of active regulators of metabolism. Many toxins are endonucleases that target cellular mRNA and tRNAs, while the antitoxins tightly wrap around the toxins to inhibit them under normal circumstances.
C. Dienemann +4 more
semanticscholar +5 more sources
Transcriptome profiling of Nudix hydrolase gene deletions in the thermoacidophilic archaeon Sulfolobus acidocaldarius [PDF]
Frontiers in Microbiology, 2023 Nudix hydrolases comprise a large and ubiquitous protein superfamily that catalyzes the hydrolysis of a nucleoside diphosphate linked to another moiety X (Nudix).
Ruth Breuer +5 more
doaj +2 more sources
Insights into toxin-antitoxin systems in the genus Bifidobacterium [PDF]
Applied and Environmental MicrobiologyToxin-antitoxin (TA) systems are widespread genetic modules in prokaryotes, implicated in diverse functions including stress adaptation, genome stability, and virulence.
Claudia Lefimil, Paula Bustamante
doaj +2 more sources
Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis [PDF]
Communications BiologyThe expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26 TA modules of M. tuberculosis.
Arun Sharma +6 more
doaj +2 more sources
Role of VapBC4 toxin-antitoxin system of Sulfolobus acidocaldarius in heat stress adaptation [PDF]
mBioToxin-antitoxin (TA) systems are important for stress adaptation in prokaryotes, including persistence, antibiotic resistance, pathogenicity, and biofilm formation.
Arghya Bhowmick +7 more
doaj +2 more sources
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. [PDF]
PLoS Genetics, 2009 Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial genomes, are unusually abundant in the major human pathogen Mycobacterium tuberculosis. Why M.
Holly R Ramage +2 more
doaj +11 more sources