<i>Salmonella</i> serovar Infantis REPJFX01 isolates bear a pESI plasmid that includes additional genes not found in closely related non-REP strains. [PDF]
Schumann A, Wiedmann M, Orsi RH.
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Harnessing toxin-mediated ribosome stalling as a complementary tool to annotate bacterial ORFs. [PDF]
Troian EA +7 more
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Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis. [PDF]
Sharma A +6 more
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A type VI secretion ADP-ribosyltransferase Rhs toxin selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding. [PDF]
Chabalier M +3 more
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Comparative Genomics Reveal Distinct Environment Preference and Functional Adaptation Among Lineages of Gemmatimonadota. [PDF]
Du J +5 more
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Enteric Virulence Associated Protein VapC Inhibits Translation by Cleavage of Initiator tRNA [PDF]
Eukaryotic PIN (PilT N-terminal) domain proteins are ribonucleases involved in quality control, metabolism and maturation of mRNA and rRNA. The majority of prokaryotic PIN-domain proteins are encoded by the abundant vapBC toxin—antitoxin loci and inhibit translation by an unknown mechanism ...
Kristoffer S Winther, Kenn Gerdes
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Growth-Regulating Mycobacterium tuberculosis VapC-mt4 Toxin Is an Isoacceptor-Specific tRNase [PDF]
Toxin-antitoxin (TA) systems are implicated in the downregulation of bacterial cell growth associated with stress survival and latent tuberculosis infection, yet the activities and intracellular targets of these TA toxins are largely uncharacterized. Here, we use a specialized RNA-seq approach to identify targets of a Mycobacterium tuberculosis VapC TA
Bryce Nickels +2 more
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VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage
Archives of Microbiology, 2022Mycobacterium tuberculosis is an extremely successful pathogen known for its ability to cause latent infection. The latter is connected with the bacterium resting state development and is considered to be based on the activity of toxin-antitoxin (TA) systems at least in part.
Mikhail Zamakhaev +5 more
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