Results 111 to 120 of about 877 (123)

Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin–Antitoxin System, Including the Development of an Inhibitor That Activates VapC

Journal of Medicinal Chemistry, 2020
Klebsiella pneumoniae is one of the most critical opportunistic pathogens. TA systems are promising drug targets because they are related to the survival of bacterial pathogens. However, structural information on TA systems in K. pneumoniae remains lacking; therefore, it is necessary to explore this information for the development of antibacterial ...
Sung-Min Kang, Chenglong Jin, Do-Hee Kim, Yuno Lee, Bong-Jin Lee   +4 more
openaire   +2 more sources

Co‐expression and purification of a toxin‐antitoxin VapC–VapB complex from the E. coli O145:H28 strain RM12581 associated with a Romain lettuce outbreak.

The FASEB Journal, 2020
VapC and VapB are the toxin and anti‐toxin proteins, respectively, of the VapCB toxin–antitoxin system found in bacteria and associated with stunting cell growth during stressful conditions. VapC homologs typically are tRNA endonucleases, and VapB homologs are known to bind to double‐stranded DNA, as well as VapC to inihibit its ...
Seth Patrick Jones, Christian Goossen, Sean Lewis, Annie Delaney, Michael Gleghorn   +4 more
openaire   +1 more source

VaPCE: Validation tool for postcoordinated SNOMED CT expressions (Preprint)

BACKGROUND The digitalization of healthcare has increased the demand for efficient data exchange, emphasizing semantic interoperability. SNOMED CT, a comprehensive terminology with over 360,000 medical concepts, supports this need. But it cannot cover all medical scenarios, particularly in complex cases.
Tessa Ohlsen, Viola Hofer, Josef Ingenerf   +2 more
openaire   +1 more source

Integrated host–phage RNA seq analysis of Mycobacteriophage D29 infection reveals dual-arm balanced phage genome expression and inhibited expression of host transporter and VapC target genes

ABSTRACT The Mycobacteriophage D29 infects Mycobacterium species. Many of these are deadly human pathogens. In earlier studies, we performed proteomic analyses using a temperature-sensitive variant of D29, called D29ts12.
Rahul Shaw, Shrestha Ghosh, Subhajit Dutta, Anirban Ghosh, Sujoy K. Das Gupta   +4 more
openaire   +1 more source

Mycobacterium tuberculosis Rv0229c Shows Ribonuclease Activity and Reveals Its Corresponding Role as Toxin VapC51

Antibiotics, 2023
Sung-Min Kang
exaly  

Ингибирование токсина VapC – способ предотвращения образования покоящихся форм микобактерий

Прикладная биохимия и микробиология, 2016
openaire   +1 more source

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

Nature Communications, 2013
Kristoffer Skovbo Winther, Ditlev E Brodersen, Kenn Gerdes   +2 more
exaly  

VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

Frontiers in Microbiology, 2020
Gopinath Chattopadhyay, Pankaj Chopra, Munmun Bhasin   +2 more
exaly  

Faculty Opinions recommendation of Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2011
Ambrose Cheung, Niles Donegan
openaire   +1 more source

In Silico Analysis of Genetic VapC Profiles from the Toxin-Antitoxin Type II VapBC Modules among Pathogenic, Intermediate, and Non-Pathogenic Leptospira

Microorganisms, 2019
Alexandre P Y Lopes, Ana Lucia Nascimento, Deborah Kohn Damiano   +2 more
exaly