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VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage
Archives of Microbiology, 2022Mycobacterium tuberculosis is an extremely successful pathogen known for its ability to cause latent infection. The latter is connected with the bacterium resting state development and is considered to be based on the activity of toxin-antitoxin (TA) systems at least in part.
Mikhail Zamakhaev +2 more
exaly +3 more sources
Are all VapC toxins of Mycobacterium tuberculosis endowed with enigmatic RNase activity?
Journal of BiosciencesMycobacterium tuberculosis (M. tb) employs an extensive network of more than 90 toxin-antitoxin systems, and among them, VapC toxins are the most abundant. While most VapCs function as classical RNases with toxic effects, a significant number of them do not exhibit toxicity.
Nasreen Ehtesham
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Resonance assignments of a VapC family toxin from Clostridium thermocellum
Biomolecular NMR Assignments, 2016Toxin-antitoxin (TA) systems widely exist in bacterial plasmids, phages, and chromosomes and play important roles in growth persistence and host-pathogen interaction. Virulence associated protein BC (VapBC) family TAs are the most abundant TAs in bacteria and many pathogens contain a large number of vapBC loci in the genome which have been extensively ...
Chen Wang +3 more
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Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides
ACS Chemical Biology, 2020Toxin-antitoxin (TA) systems have been considered essential factors for bacterial survival. During our drug development program aimed against tuberculosis (TB), we discovered certain peptides that mimic the binding of the VapBC30 complex, leading to the arrest of bacterial cell growth and eventually cell death.
Sung-Min Kang +5 more
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Veterinary and Comparative Oncology, 2023
AbstractThe most commonly utilized protocols to treat lymphoma in cats employ vincristine, cyclophosphamide and prednisone; with additional drugs sometimes used including L‐asparaginase and doxorubicin. Medical records were reviewed for 55 cats with alimentary lymphoma treated with a novel multiagent protocol using prednisolone, L‐asparaginase ...
Antony Stewart Moore +1 more
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AbstractThe most commonly utilized protocols to treat lymphoma in cats employ vincristine, cyclophosphamide and prednisone; with additional drugs sometimes used including L‐asparaginase and doxorubicin. Medical records were reviewed for 55 cats with alimentary lymphoma treated with a novel multiagent protocol using prednisolone, L‐asparaginase ...
Antony Stewart Moore +1 more
openaire +2 more sources
Structural analysis of the active site architecture of the VapC toxin from
ABSTRACTThe VapC toxin from the Shigella flexneri 2a virulence plasmid pMYSH6000 belongs to the PIN domain protein family, which is characterized by a conserved fold with low amino acid sequence conservation. The toxin is a bona fide Mg2+‐dependent ribonuclease and has been shown to target initiator tRNAfMet in vivo. Here, we present crystal structures
Xu, Kehan +2 more
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Molecular Microbiology, 2009
SummaryToxin–antitoxin loci have been identified in almost all free‐living prokaryotes, often in high copy numbers. The biological function and molecular targets of the abundant vapBC loci are not yet known. Here we analyse the vapBC loci of Salmonella LT2 and Shigella plasmid pMYSH6000.
Winther KS, Gerdes K
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SummaryToxin–antitoxin loci have been identified in almost all free‐living prokaryotes, often in high copy numbers. The biological function and molecular targets of the abundant vapBC loci are not yet known. Here we analyse the vapBC loci of Salmonella LT2 and Shigella plasmid pMYSH6000.
Winther KS, Gerdes K
openaire +3 more sources
VapC toxin inhibition as a method for prevention of the formation of resting forms of mycobacteria
Applied Biochemistry and Microbiology, 2016It has been shown that inactivation of the VapC toxin from the VapВС toxin-antitoxin system prevents mycobacterial cells from transitioning to an ovoid state that meets the criteria of dormancy. The results indicate a potential target for medicines that prevent the development of latent tuberculosis infection and provide a basis to obtain bacterial ...
O I, Demidenok +2 more
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