Results 71 to 80 of about 8,222 (211)

Counterfeiting honey with phosphodiesterase inhibitors for sexual activity enhancement: detection using high-performance liquid chromatography coupled with a photodiode array detector (HPLC-PAD) [PDF]

Journal of Men's Health
Globally, there have been several reports of natural products contaminated with illegal adulterants that threaten consumer health because of their adverse pharmacological effects.
Abdullah M. Alkhalaf, Fouza K. Alenazi, Mubarak M. Abudahash, Reem Alfadhli, Ghadah H. Altoum, Naif D. Alenzi   +5 more
doaj   +1 more source

Antifibrotic synergy between phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators in Peyronie’s disease models [PDF]

, 2019
Background: Peyronie's disease (PD) is a fibrotic disorder of the penile tunica albuginea, characterised by the formation of a localised fibrous plaque that can lead to deformity and erectile dysfunction.
Albersen, Maarten, Cellek, Selim, Christopher, Nim, Ilg, Marcus M., Mateus, Marta, Milenkovic, Uros, Muneer, Asif, Ralph, David J., Stebbeds, William J.   +8 more
core   +2 more sources

Phosphodiesterase‐5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study

Aging Cell, Volume 24, Issue 12, December 2025.
Preclinical studies suggest PDE5 inhibitors may improve cognition, but observational evidence on Alzheimer's disease (AD) risk is mixed. We performed a cis‐Mendelian randomisation analysis across four AD genome‐wide association studies (GWAS) datasets and a sex‐stratified analysis using UK Biobank data.
Marta Alcalde‐Herraiz, Benjamin Woolf, Junqing Xie, Emma Anderson, Dipender Gill, Ioanna Tzoulaki, Laura M. Winchester, James Yarmolinsky, Daniel Prieto‐Alhambra, Danielle Newby   +9 more
wiley   +1 more source

Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors

Current Therapeutic Research, 2015
Background: Ciprofloxacin is a commonly used antibiotic for urinary tract infection that interacts with bacterial topoisomerases leading to oxidative radicals generation and bacterial cell death.
Majed M. Masadeh, PhD, Karem H. Alzoubi, PhD, Omar F. Khabour, Sayer I. Al-Azzam, Msc   +3 more
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors Greatly Affect Physicochemical Properties of Model Lipid Membranes

Membranes, 2021
Although phosphodiesterase type 5 inhibitors are widely used and well-studied drugs, the potential benefits of their application in the treatment of various diseases and new drug delivery systems, including liposome forms, are still being discussed.
Anastasiia A. Zakharova, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Authenticating medicines with dual laser handheld Raman spectroscopy [PDF]

, 2016
The World Health Organisation (WHO) defines counterfeit medicines as those that have been "deliberately and fraudulently mislabelled according to identity or source'"1.
Assi, Sulaf
core  

A Systematic Literature Review Exploring the Efficacy and Safety of Tadalafil and Sildenafil in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Pulmonary Arterial Hypertension (PAH) is a rare, chronic and progressive disease affecting the heart and lungs. Endothelin receptor antagonist (ERA) + phosphodiesterase type 5 inhibitor (PDE5i) treatment is recommended for all PAH patients. The two approved PDE5is are tadalafil and sildenafil.
Rajan Saggar, Nora Rahhali, Assunta Senatore, Marinella Sandros, David Lopez, Gabriela Gomez Rendon, Ambar Khan, Ellie Boulton, Anna Bobrowska, Sandeep Sahay   +9 more
wiley   +1 more source

The current treatment of erectile dysfunction [PDF]

, 2016
Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age.
Benea, Vasile, Georgescu, Simona R., Mitran, Cristina I., Mitran, Mădălina I., Sarbu, Maria Isabela, Tampa, Mircea   +5 more
core   +2 more sources

Novel PDE4 inhibitors derived from Chinese medicine Forsythia [PDF]

, 2014
Cyclic adenosine monophosphate (cAMP) is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal transduction pathways generating cell- and stimulus-specific effects.
Birru, RL, Chen, BB, Coon, TA, Lear, T, Leikauf, GD, McKelvey, AC, Weathington, NM   +6 more
core   +1 more source