Results 51 to 60 of about 3,797 (199)

Addition of vardenafil into storage solution protects the endothelium in a hypoxia-reoxygenation model [PDF]

, 2013
OBJECTIVE: Based upon the well known protective effect of intracellular cyclic guanosine monophosphate (cGMP) accumulation, we tested the hypothesis that storage solution enriched with optimal concentration of the phosphodiestherase-5 inhibitor ...
Korkmaz S, Veres, Gábor, Radovits, Tamás, Barnucz E, Hegedűs, P., Karck, M., Barnucz, E., Radovits Tamás, Barnucz, Enikó, Hegedus P, Zoller R, Weymann, A., Karck, Matthias, Radovits, T., Korkmaz, Sevil, Veres Gábor, Kolonics, F., Szabó, G., Veres, G., Korkmaz, S., Weymann, Alexander, Zöller, R., Szabo, Gabor, Weymann A, Kolonics F, Szabo G, Zöller, Raphael, Karck M   +27 more
core   +1 more source

Advances in Erectile Dysfunction Management: What Does Work

Trends in Urology &Men's Health, Volume 17, Issue 3, June 2026.
ABSTRACT Erectile dysfunction (ED) is a prevalent and multifactorial disorder that substantially affects quality of life. Pathophysiology includes vascular, neurogenic, drug‐induced, and psychogenic causes, and frequently coexists with cardiometabolic disease.
Jolie Shen, Daye Park, Jasper Bash, Juan Andino   +3 more
wiley   +1 more source

The Vascular‐Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
This review synthesizes current evidence showing how vascular–immune cell crosstalk and microenvironmental cues shape pulmonary vascular remodeling in pulmonary hypertension. We provide an integrative perspective that positions disrupted cellular communication as a central driver of disease progression and a promising source of future therapeutic ...
Lola Navarro‐Llinares, Bertha García‐León, Laura de la Bastida‐Casero, Eduardo Oliver   +3 more
wiley   +1 more source

Effect of vardenafil on Herceptin therapy in metastatic brain tumor-bearing mice.

, 2013
(a) Effect of vardenafil on the survival rates of CRL-5904 metastatic brain tumor-bearing mice. Groups of mice (control, n = 12; Herceptin, n = 10; vardenafil, n = 10; Herceptin + vardenafil, n = 12) were treated with saline, Herceptin (10 mg/kg, i.v ...
Rameshwar Patil (332922), Jinwei Hu (365467), Satoshi Inoue (221875), Alexander V. Ljubimov (365469), Julia Y. Ljubimova (332939), Hui Ding (308976), Andres Espinoza (332927), Chirag Patil (365468), Bindu Konda (332925), Keith L. Black (247910), Kolja A. Wawrowsky (242556)   +10 more
core   +1 more source

Peripheral Arterial Tonometry to Measure the Effects of Vardenafil on Sympathetic Tone in Men with Lifelong Premature Ejaculation

International Journal of Endocrinology, 2013
To elucidate whether adrenergic overtone is involved in the pathophysiology of men with lifelong (LL) premature ejaculation (PE), we investigated differences in reactive hyperemia index (RHI) responses by using peripheral arterial tonometry (PAT). 20 men
Davide Francomano, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa   +3 more
doaj   +1 more source

Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Farouk Boudou, Alaeddine Berkane, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, Brian A. Murray, Mikhael Bechelany, Ahmed Barhoum   +7 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men

Andrology, Volume 14, Issue 2, Page 466-479, February 2026.
Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu, Suping Niu, Fan Huang, Lu Jin, Qun Gu, Yanting Li, Chongyou Lee, Zhenwei Xie, Xiangxing Liu, Fang Men, Wenyan Zhao, Shuang Li, Yian Liu, Qian Wang, Huaying Fan, Jiaojiao Zhang, Shuangshuang Lin, Liming Chen, Yi Fang   +18 more
wiley   +1 more source

No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Lan Gao, Hongqi Xue, Borje Darpo, Kimberly Ingalls, Diksha Kaushik, Neil Smith, Ronald Kong, Lee Golden   +7 more
wiley   +1 more source

Protective Effects of the Aqueous Extract of Tribulus cistoides (Zygophyllaceae) Against Nicotine‐Induced Fertility Impairment in Male Wistar Rats

Andrologia, Volume 2026, Issue 1, 2026.
Infertility affects a substantial proportion of couples worldwide and is defined as the failure to achieve pregnancy after 1 year of regular, unprotected sexual intercourse. Growing interest has been directed toward ethnobotanical approaches for the management of male infertility. This study evaluated the therapeutic potential of the aqueous extract of
Kiafon Betrand Nsah, Nguedem Sylvie Fonkwo, Njoya Moses Tita Mogho, Tangu Patience Neng, Mumbi Laurantine Ngenteh, Ndifor Rose Nchang, Bih Belta Lilian Fubi, Kada Sanda Antoine, Harleen Khatra   +8 more
wiley   +1 more source

Kombinationstherapie der pulmonalarteriellen Hypertonie mit Vardenafil und Bosentan in einem ex-vivo/in-vitro-Setting [PDF]

, 2020
Hintergrund: Die medikamentöse Behandlung der pulmonalarteriellen Hypertonie (PAH) setzt sich aus unterschiedlichen Substanzklassen zusammen, insbesondere Endothelin-Rezeptor-Antagonisten und Phosphodiesterase-5-Inhibitoren.
Stadlbauer, Christian Thomas
core   +1 more source