Validity and reliability of telephone administration of the patient-specific functional scale for the assessment of recovery from snakebite envenomation [PDF]
, 2019 OBJECTIVES: Although more than 1.8 million people survive snakebite envenomation each year, their recovery is understudied. Obtaining long-term follow-up is challenging in both high- and low-resource settings. The Patient-Specific Functional Scale (PSFS)
et al., +2 more
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Clinical management of snakebite envenoming: Future perspectives
Toxicon: X, 2021 Snakebite envenoming is a major cause of morbidity and mortality in rural communities throughout the tropics. Generally, the main clinical features of snakebites are local swelling, tissue necrosis, shock, spontaneous systemic hemorrhage, incoagulable ...
Muhammad Hamza +6 more
doaj +1 more source
Flipping the odds of drug development success through human genomics [PDF]
, 2017 Drug development depends on accurately identifying molecular targets that both play a causal role in a disease and are amenable to pharmacological action by small molecule drugs or bio-therapeutics, such as monoclonal antibodies.
Casas, JP +12 more
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The Year in Cardiology 2013: cardiovascular disease prevention [PDF]
, 2017 The decline in cardiovascular mortality in Europe by nearly 50% over the last three decades resulted in particular from improved risk factor control and prevention interventions in addition to improved treatment.
Gielen, S., Landmesser, U.
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Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. ПавловаSnake venoms have long been the subject of research in order to obtain new antitumor compounds. Snake secretory phospholipase A2 has cytotoxic properties that are realized through different mechanisms depending on the enzyme structure and cell type. HeLa
M. A. Solovyeva +5 more
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Recent Advances in Next Generation Snakebite Antivenoms
Tropical Medicine and Infectious Disease, 2018 With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies.
Cecilie Knudsen, Andreas H. Laustsen
doaj +1 more source
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy [PDF]
, 2020 In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, which recommend the use of ...
Ainsworth +6 more
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Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection [PDF]
, 2014 The role of Group X secreted phospholipase A2 (GX-sPLA2) during influenza infection has not been previously investigated. We examined the role of GX-sPLA2 during H1N1 pandemic influenza infection in a GX-sPLA2 gene targeted mouse (GX−/−) model and found ...
Angoulvant, Denis +15 more
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Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort. [PDF]
, 2019 OBJECTIVE: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify ...
Chung, Olivia +6 more
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Experimental and computational studies on lipoprotein lipolysis at acidic pH [PDF]
, 2010 Atherosclerosis is a disease of the arteries; its characteristic features include chronic inflammation, extra- and intracellular lipid accumulation, extracellular matrix remodeling, and an increase in extracellular matrix volume.
Lähdesmäki, Katariina
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