Results 81 to 90 of about 721 (146)
Recent Advances in Next Generation Snakebite Antivenoms
Tropical Medicine and Infectious Disease, 2018 With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies.
Cecilie Knudsen, Andreas H. Laustsen
doaj +1 more source
, 2022 The venoms of Asiatic kraits (Bungarus spp.) contain various neurotoxic phospholipases A(2) (beta-bungamtoxins) which can irreversibly damage motor nerve terminals, resulting in rapidly fatal suffocation by respiratory muscle paralysis or oral airway ...
Tan, Kae Yi +2 more
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Histopathology images for Hall, et al., 2022
, 2022 Data respository containing over 700 images of 100x magnified brightfield microscope images of H&E stained dermal cross-sections from mice ID-injected with different cytotoxic snake venoms with or without drug therapies to determine their inhibitory ...
Steven Hall (12494206)
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ACS Applied Materials & InterfacesOsteoarthritis (OA) is often associated with chronic, unresolved inflammation in joint tissues, leading to cartilage degeneration. Secretory phospholipase A2 (sPLA2) plays a crucial role in the pathogenesis of inflammatory diseases, and we previously found its amount in articular cartilage to be much higher in OA samples than healthy ones.
Qiushi Liang +10 more
openaire +3 more sources
Evaluación del espectro y propiedades neutralizantes del Varespladib hacia fosfolipasas A2 tóxicas de venenos ofídicos [PDF]
El envenenamiento ofídico es un problema médico y de salud pública debido a su incidencia y al número de muertes que causa a nivel mundial. Las fosfolipasas A2 constituyen un porcentaje importante de los venenos de serpientes, y son las enzimas ...
Bryan Quirós, Wendy
core
Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundThe development of atherosclerosis is strongly linked to disorders of cholesterol metabolism. Matrix metalloproteinases (MMPs) are dysregulated in patients and animal models with atherosclerosis.
Samuel Hernandez‐Anzaldo +10 more
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A concise review on copper catalyzed synthesis of α-ketoamides
Applied Catalysis O: OpenThe α-ketoamides are essential building blocks for the synthesis of β-lactams and oxazolidinones. As it contains multiple reactive centers, it could be a suitable starting material for following reactions such as Michael addition reaction, Pictet ...
Amit Gautam +4 more
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Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
, 2020 A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering envenomations globally. LY315920 (Varespladib, S-5920, A-001), a low molecular weight drug developed to inhibit several human secreted ...
Bryan Quirós, Wendy +4 more
openaire +2 more sources
Neutralizing properties of Varespladib toward group I and II myotoxic phospholipases A2
, 2019 A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering envenomations globally.
Bryan Quirós, Wendy +4 more
core +1 more source