Results 61 to 70 of about 721 (146)

Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)

Toxins, 2018
Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it has been the most neglected of tropical diseases.
Mátyás A. Bittenbinder, Christina N. Zdenek, Bianca op den Brouw, Nicholas J. Youngman, James S. Dobson, Arno Naude, Freek J. Vonk, Bryan G. Fry   +7 more
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

58 Effect of Varespladib-Protected Surfactant in Cultured Rat Alveolar Macrophages Stimulated with LPS [PDF]

Archives of Disease in Childhood, 2012
Background Secretory phospholipase A2 (sPLA2) is a crucial enzyme for inflammatory response and surfactant catabolism. Acute lung injury (ALI) is a life-threating syndrome characterized by surfactant dysfunction and raised levels of sPLA2. Varespladib is a potent selective sPLA2 inhibitor that is effective in animal models of ALI.
Luca, D. D., Vendittelli, F., Fraser, H., Gentile, L., Trias, J., Minucci, A., Capoluongo, E.   +6 more
openaire   +2 more sources

Polymeric Nanoparticles for the Diagnosis and Treatment of Snakebite

Macromolecular Chemistry and Physics, Volume 227, Issue 1, 15 January 2026.
Snakebite envenomation affects between 1.8 and 5.5 million people annually, many of whom suffer disabilities or even death. Current antivenoms are composed of plasma‐derived antibodies. However, there remains an underexplored opportunity to utilise polymer‐based nanoparticles.
Neil Prabhakar, Thomas Oliver, Alexander N. Baker   +2 more
wiley   +1 more source

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Acta Pharmaceutica Sinica B, 2020
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific ...
Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +1 more source

Peripheral Arterial Thrombosis following Russell's Viper Bites

TH Open, 2023
Envenomings by Russell's viper (Daboia russelii), a species of high medical importance in India and other Asian countries, commonly result in hemorrhage, coagulopathies, necrosis, and acute kidney injury.
Subramanian Senthilkumaran, Ketan Patel, Elanchezhian Rajan, Pradeep Vijayakumar, Stephen W. Miller, Alexandra Rucavado, Soheil Gilabadi, Medha Sonavane, Nicholas J. Richards, Jarred Williams, Harry F. Williams, Steven A. Trim, Ponniah Thirumalaikolundusubramanian, José María Gutiérrez, Sakthivel Vaiyapuri   +14 more
doaj   +1 more source

A Case Report of Postpartum Hemorrhage Secondary to Snake Bite Envenomation: A Pathogenesis and Current Management Review

Case Reports in Obstetrics and Gynecology, Volume 2026, Issue 1, 2026.
Background Snakebite envenomation (SBE) is a tropical disease with significant global morbidity and mortality, particularly affecting low‐resource settings. During pregnancy, SBE poses unique challenges, increasing both maternal and fetal mortality. Limited access to antivenom and delayed treatment further worsen outcomes.
Felipe Loza-Hernandez, Alexis Haro, Gabriela Carrión, Homero Loza, Karuna Sharma   +4 more
wiley   +1 more source

Functional and structural characterization of toxins from Bothrops jararacussu snake venom and influence of varespladib

, 2023
According to the World Health Organization, there are approximately 5.4 million snake bites each year, resulting in 2.7 million poisonings and 100.000 deaths.
Êmylle Karoline Ramos Pinto
core  

Correction: Wang et al. Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation. Molecules 2018, 23, 391

Molecules, 2022
The authors would like to correct an error in the original publication [...]
Yiding Wang, Jing Zhang, Denghong Zhang, Huixiang Xiao, Shengwei Xiong, Chunhong Huang   +5 more
doaj   +1 more source

Phospholipase A2 Inhibitors as Potential Treatment of Psoriasis

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
The phospholipase A2 (PLA2) enzyme family plays a crucial role in the production of bioactive lipids that are involved in maintaining the epidermal barrier function and regulating inflammation and immune responses in the skin. Therefore, aberrant PLA2 expression and activity have been implicated in various skin diseases including psoriasis. This review
Chantalle Crous, Judey Pretorius, Anél Petzer, Suraiya Saleem   +3 more
wiley   +1 more source