Results 1 to 10 of about 2,105 (188)

Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
José Rafael de Almeida, Sakthivel Vaiyapuri, Ketan Patel   +2 more
exaly   +7 more sources

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops [PDF]

eLife
Snakebite globally claims more than 100,000 lives per year and results in morbidity for 400,000 survivors. Current treatment uses antibody-based antivenoms which are constrained by their efficacy, safety, and cost. In this study we evaluated the efficacy
Rachel H Clare, Adam Westhorpe, Emma Stars, Taline D Kazandjian, Laura-Oana Albulescu, Stefanie K Menzies, Nicholas R Casewell   +6 more
doaj   +2 more sources

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin [PDF]

Advanced Science
The layered structure of skin necessitates highly sophisticated tissue coordination during regeneration. The unmet clinical need of long‐term skin expansion therapy stems from limited regenerative capacity, yet the underlying mechanism remains enigmatic ...
Yidan Sun, Qili Qian, Luwen Xu, Bowen Gao, Ting Li, Yin Li, Jiayi Zheng, Qiaoyu Fu, Xi Cheng, Nuo Chen, Sijia Wang, Liang Zhang, Caiyue Liu, Qingfeng Li   +13 more
doaj   +2 more sources

Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach [PDF]

Smart Medicine
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives.
Lidan Hu, Yifan Zhu, Chengpeng Wu, Xiao Liu, Qi Wang, Yangyiyi Huang, Hongyan Liu, Xiangjun Chen, Wei Wu, Hua Jiang   +9 more
doaj   +2 more sources

Angiotensin II Disrupts Axo-Axonal Interaction-Mediated Vasorelaxation in Basilar Arteries of Normotensive and Hypertensive Rats [PDF]

Biomedicines
Background/Objectives: The renin–angiotensin–aldosterone (RAA) system is a key regulator of cardiovascular homeostasis. Recent evidence suggests that Angiotensin II (Ang II) can trigger ferroptosis, an iron-dependent form of cell death.
Stephen Shei-Dei Yang, Kuan-Yu Chen, Earl Fu, Hsi-Hsien Chang, Kuo-Feng Huang   +4 more
doaj   +2 more sources

Multi-omics prediction of key proteases regulating scar formation and neural repair after spinal cord injury [PDF]

Neural Regeneration Research
Neurological injury is often accompanied by extensive infiltration of macrophages along with activation of fibroblasts and endothelial cells. The activity of these cells is associated with elevated levels of various proteases, which contribute to the ...
Huan Jian, Jiahao Ren, Jiawei Du, Kailin Wu, Shen Liu, Yuanting Zhao, Hengxing Zhou, Shiqing Feng   +7 more
doaj   +2 more sources

Preclinical evaluation of small molecule inhibitors as early intervention therapeutics against Russell’s viper envenoming in India [PDF]

Communications Medicine
Background Snakebites are problematic in many developing regions, including India, where over half of global snakebite deaths occur. Antivenoms are currently the only licensed treatment for snakebites.
Gotravalli V. Rudresha, Suyog Khochare, Nicholas R. Casewell, Kartik Sunagar   +3 more
doaj   +2 more sources

The EGFR Signaling Pathway Is Involved in the Biliary Intraepithelial Neoplasia Associated with Liver Fluke Infection [PDF]

Pathogens
Foodborne trematode infections are recognized as a significant risk factor for cholangiocarcinoma (CCA) in endemic regions. Infection with the liver fluke Opisthorchis felineus induces precursor lesions of CCA, including the biliary intraepithelial ...
Dmitry Ponomarev, Oxana Zaparina, Anna Kovner, Elena Hadieva, Mikhail Persidskij, Maria Pakharukova   +5 more
doaj   +2 more sources

Electrical Cell Impedance Sensing (ECIS): Feasibility of a Novel In Vitro Approach to Studying Venom Toxicity and Potential Therapeutics [PDF]

Toxins
Snakebite envenoming is often discussed in terms of lethality and limb loss, but local tissue injury and coagulotoxic effects of venom are significantly more common acute manifestations of snakebite envenoming (SBE).
Abhinandan Choudhury, Kaitlin Linne, Tommaso C. Bulfone, Tanvir Hossain, Abu Ali Ibn Sina, Philip L. Bickler, Bryan G. Fry, Matthew R. Lewin   +7 more
doaj   +2 more sources

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

Toxicon: X, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Stefanie K. Menzies, Rachel H. Clare, Chunfang Xie, Adam Westhorpe, Steven R. Hall, Rebecca J. Edge, Jaffer Alsolaiss, Edouard Crittenden, Amy E. Marriott, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +11 more
doaj   +1 more source