Results 91 to 100 of about 721 (146)

High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis

Journal of Translational Medicine
Background In mouse models of atherosclerosis, knockout of the PLA2G2A gene has been shown to reduce the volume of atherosclerotic plaques. Clinical trials have demonstrated the potential of using the sPLA2 inhibitor Varespladib in combination with ...
Xin Wang, Shen Li, Chen Liu, Jiawei Zhao, Gangfeng Ren, Feng Zhang, Xuyang Liu, Shuang Cao, Yuming Xu, Zongping Xia   +9 more
doaj   +1 more source

In Vitro Efficacy of Antivenom and Varespladib in Neutralising Chinese Russell’s Viper (Daboia siamensis) Venom Toxicity

The venom of the Russell's viper (Daboia siamensis) contains neurotoxic and myotoxic phospholipase A2 toxins which can cause irreversible damage to motor nerve terminals.
Wayne C. Hodgson (412268), Mimi Lay (21284309), Geoffrey Isbister (21130406), Qing Liang (654718)   +3 more
core  

Targeting Key Enzymatic Snake Venom Proteins Using Repurposed Small Molecule Inhibitors: Emerging Adjuncts to Antivenom Therapy. [PDF]

Int J Mol Sci
Reghu N, Kiruthika S, Santhosh AK, Narayanan AL, Geetha KG, Sidheek N, Danthuluri SS, Nair BG, Vanuopadath M.   +8 more
europepmc   +1 more source

Why does local edema persist? Immunological mismatch between phospholipase A2 potency and antivenom affinity in Protobothrops mucrosquamatus envenomation. [PDF]

PLoS Negl Trop Dis
Ho CH, Chiang YW, Mao YC, Hsu CH, Chen FC, Tsai SH, Liu SH.   +6 more
europepmc   +1 more source

<i>Bothrops</i> venom variation drives niche-specific pharmacology through Ca²⁺ signalling and membrane damage. [PDF]

Front Pharmacol
Bourke LA, Slagboom J, Waller MA, Neely GG, Kool J, Cardoso FC.   +5 more
europepmc   +1 more source

Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Alangode A, Rajasekhar A, Sabu JJ, Krishna S, Anuja D, Sreeja A, Remesh G, Kaladevi A, Nair BG.   +8 more
europepmc   +1 more source

Ruthenium Compounds Differentially Inhibit Group IA and IIA Snake Venom Phospholipase A₂ Anticoagulant Activity. [PDF]

Int J Mol Sci
Nielsen VG, Nielsen SA.
europepmc   +1 more source

Anti-inflammatory therapies to prevent cardiovascular events: systematic review and network meta-analysis of randomised controlled trials. [PDF]

Front Cardiovasc Med
Boczar KE, Pearson AL, Hakimjavadi R, Shin S, Shahab S, Geejo A, Visintini SM, Fehlmann CA, Bezzina KA, Beanlands RSB, Wells GA.   +10 more
europepmc   +1 more source

Large animal models for the assessment of snakebite envenoming therapies. [PDF]

NPJ Drug Discov
Benard-Valle M, Ahmadi S, Modahl CM, Neri-Castro E, Alagón A, Boyer L, Ljungars A, Laustsen AH.   +7 more
europepmc   +1 more source

Reshaping antivenom therapy: A triple-synergy strategy featuring broadly neutralizing antibodies and a small-molecule PLA₂ inhibitor. [PDF]

Acta Pharm Sin B
Zhou Y, Shi N, Gao X, Luo L.
europepmc   +1 more source