Ex vivo effect of varespladib on secretory phospholipase A2 alveolar activity in infants with ARDS. [PDF]
PLoS ONE, 2012 Secretory phospholipase A2 (sPLA2) plays a pivotal role in acute respiratory distress syndrome (ARDS). This enzyme seems an interesting target to reduce surfactant catabolism and lung tissue inflammation.
Daniele De Luca +9 more
doaj +7 more sources
Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom [PDF]
Frontiers in Pharmacology, 2022 Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a potential antivenom support agent to prevent PLA2-dependent effects produced by ...
Pamella G. Gutierres +10 more
doaj +3 more sources
Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation [PDF]
Toxins, 2016 Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a century of calls to improve snakebite prevention and care.
Matthew Lewin +3 more
doaj +3 more sources
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms [PDF]
Nature Communications, 2023 Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R. Hall +9 more
doaj +5 more sources
Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib) [PDF]
Toxins, 2018 Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it has been the most neglected of tropical diseases.
Mátyás A. Bittenbinder +7 more
doaj +3 more sources
ACS Applied Materials & InterfacesOsteoarthritis (OA) is often associated with chronic, unresolved inflammation in joint tissues, leading to cartilage degeneration. Secretory phospholipase A2 (sPLA2) plays a crucial role in the pathogenesis of inflammatory diseases, and we previously ...
Qiushi Liang (1799506) +10 more
semanticscholar +5 more sources
Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis [PDF]
Mediators of Inflammation, 2021 Introduction and Hypothesis. The role of inflammation is widely recognized in the pathogenesis of coronary artery disease. Research on animal models had shown the potential benefits of targeting specific inflammatory pathways.
Ivan Wudexi +4 more
doaj +4 more sources
The synergistic inhibition of atherogenesis in apoE−/− mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)[S] [PDF]
Journal of Lipid Research, 2009 Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease.
Zory Shaposhnik +4 more
doaj +5 more sources
Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920) [PDF]
Scientific Reports, 2019 The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030.
Daniela P. Marchi‐Salvador +7 more
semanticscholar +6 more sources
4 Oral Varespladib for Snakebite Envenoming: The BRAVO International Randomized Controlled Trial [PDF]
Annals of Emergency Medicine, 2023 Charles J. Gerardo +9 more
semanticscholar +3 more sources