Naja atra SVPLA2 Aggravates Acute Kidney Injury Through Metabolic Reprogramming-Dependent Macrophage Polarization and Defective Efferocytosis [PDF]
ToxinsSnakebite envenoming remains a major global health challenge. Naja atra (N. atra) envenomation induces severe acute kidney injury (AKI), largely driven by snake venom phospholipase A2 (SVPLA2).
Jiahao Liu +6 more
doaj +2 more sources
The synergistic inhibition of atherogenesis in apoE−/− mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)[S] [PDF]
Journal of Lipid Research, 2009 Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease.
Zory Shaposhnik +4 more
doaj +3 more sources
Chinese cobra (Naja atra) SVPLA2 promotes muscle inflammation via RPL35A-mediated translational reprogramming [PDF]
Communications BiologyNaja atra venom induces severe myotoxicity and inflammation largely driven by snake venom phospholipase A2 (SVPLA2). Although the SVPLA2 inhibitor varespladib shows great therapeutic promise, the underlying molecular mechanisms remain unclear. Herein, we
Jiahao Liu +9 more
doaj +2 more sources
Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. [PDF]
Proc Natl Acad Sci U S A, 2023 Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ...
Bartlett KE +13 more
europepmc +10 more sources
American Journal Cardiovascular Drugs, 2011 Anthera Pharmaceuticals is developing an oral formulation of varespladib (A 001; A 002; A-001; A-002; LY 315920; LY 333013; LY315920; LY333013; S 3013; S 5920; S-3013; S-5920; Varespladib methyl) for once-daily treatment of acute coronary syndromes.
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core +3 more sources
EBV promotes alveolar trabecula resorption via extracellular vesicle remodeling by group IIA secreted phospholipase A2 [PDF]
Journal of Lipid ResearchEpstein–Barr virus (EBV) is an enveloped, double-stranded DNA virus that selectively infects primates. Periodontitis, a common inflammatory disease characterized by alveolar bone destruction, affects more than half of the global adult population.
Akane Kanamori +15 more
doaj +2 more sources
Preclinical evaluation of small molecule inhibitors as early intervention therapeutics against Russell’s viper envenoming in India [PDF]
Communications MedicineBackground Snakebites are problematic in many developing regions, including India, where over half of global snakebite deaths occur. Antivenoms are currently the only licensed treatment for snakebites.
Gotravalli V. Rudresha +3 more
doaj +2 more sources
Isolation and Pharmacological Characterisation of Pre-Synaptic Neurotoxins from Thai and Javanese Russell’s Viper (Daboia siamensis) Venoms [PDF]
ToxinsThe widespread geographical distribution of Russell’s vipers (Daboia spp.) is associated with marked variations in the clinical outcomes of envenoming by species from different countries.
Mimi Lay, Wayne C. Hodgson
doaj +2 more sources
Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation [PDF]
Toxicon: XSnakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually.
Mátyás A. Bittenbinder +7 more
doaj +2 more sources
In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib [PDF]
ToxiconBungarus (krait) envenomings are well-known for their life-threatening neurotoxic effects. However, their impact on coagulation remains largely unexplored experimentally or clinically.
Samuel, Stephen P. +7 more
core +5 more sources