Results 21 to 30 of about 721 (146)

A Comparison of the Efficacy of Antivenoms and Varespladib against the In Vitro Pre-Synaptic Neurotoxicity of Thai and Javanese Russell’s Viper (Daboia spp.) Venoms [PDF]

Toxins
The heterogeneity in venom composition and potency in disparate Eastern Russell’s viper (Daboia siamensis) populations has repercussions for the efficacy of antivenoms. This is particularly pronounced in geographical areas in which the venom of the local
Mimi Lay, Wayne C. Hodgson
doaj   +3 more sources

Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation

Toxins, 2016
Snakebite remains a neglected medical problem of the developing world with up to 125,000 deaths each year despite more than a century of calls to improve snakebite prevention and care.
Stephen Samuel, Lewin Mr
exaly   +4 more sources

A-002 (Varespladib), a phospholipase A₂ inhibitor, reduces atherosclerosis in guinea pigs [PDF]

BMC Cardiovascular Disorders, 2009
Background The association of elevated serum levels of secretory phospholipase A2 (sPLA2) in patients with cardiovascular disease and their presence in atherosclerotic lesions suggest the participation of sPLA2 enzymes in this disease.
Fraser Heather, Puglisi Michael, Vaishnav Ushma, Leite Jose O, Trias Joaquim, Fernandez Maria   +5 more
doaj   +6 more sources

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial. [PDF]

JAMA, 2014
Secretory phospholipase A2 (sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown.
Nicholls, Stephen J;Kastelein, John J P;Schwartz, Gregory G;Bash, Dianna;Rosenson, Robert S;Cavender, Matthew A;Brennan, Danielle M;Koenig, Wolfgang;Jukema, J Wouter;Nambi, Vijay;Wright, R Scott;Menon, Venu;Lincoff, A Michael;Nissen, Steven E;VISTA-16 Investigators;Hennekens, Charles;Brown, W Virgil;DeMets, David;Pfeffer, Marc;Roleau, John;Abraham, JoEllyn;Gebel, James;Huff, Christopher;Katzan, Irene;Shishehbor, Medhi;Rassi, Andrew;Uchino, Ken;Vest, Amanda;Zishiri, Edwin;Heckman, Mary Jo;Balog, Craig;Dart, Anthony;Amerena, John;Prasad, Challa;Farshid, Ahmad;Gunalingam, Brendan;Thompson, Peter;Collins, Nicholas;Arstall, Margaret;van Gaal, William;Aroney, Con;Mahar, Leo;Youssef, George;Horowitz, John;Anand, Dharmesh;Rodes-Cabau, Josep;Polasek, Petr;Lai, Christopher;Huynh, Thao;Hubacek, Jaroslav;Kokis, Andre;Paradis, Jean-Michel;Mukherjee, Ashok;Senaratne, Manohara;Constance, Christian;Gosselin, Gilbert;Lavi, Shahar;Parker, John;Zadra, Remo;Abramson, Beth;Della-Siega, Anthony;Spinar, Jindrich;Pudil, Radek;Motovs
core   +11 more sources

Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib [PDF]

BMC Biology
Background The snake genera Atropoides, Cerrophidion, and Metlapilcoatlus form a clade of neotropical pit vipers distributed across Mexico and Central America.
Lee Jones, Mimi Lay, Edgar Neri-Castro, Vanessa Zarzosa, Wayne C. Hodgson, Matthew Lewin, Bryan G. Fry   +6 more
doaj   +6 more sources

Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib

Biochimie, 2023
Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. Recently, varespladib was also found
Ortolani, Paula L., Fortes-Dias, Consuelo L., Salvador, Guilherme H.M. [UNESP], Fontes, Marcos Roberto de Mattos, Fontes, Marcos R.M. [UNESP], Soares, Andreimar M., Soares, Adreimar M., Forte Dias, Consuelo L., Cavalcante, Walter L. G., Cavalcante, Walter L.G., Lewin, Matthew R., Salvador, Guilherme Henrique Marchi, Pinto, Êmylle K. R., Lomonte, Bruno, Pinto, Êmylle K.R.   +14 more
core   +5 more sources

The synthetic Varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

Biochimica et Biophysica Acta (BBA) - General Subjects, 2021
The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local effects.
Borges, Rafael J. [UNESP], Salvador, Guilherme H.M. [UNESP], Fontes, Marcos Roberto de Mattos, Fontes, Marcos R.M. [UNESP], Lewin, Matthew R., Salvador, Guilherme Henrique Marchi, Borges, Rafael J., Lomonte, Bruno   +7 more
core   +5 more sources

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920) [PDF]

Scientific Reports, 2019
The World Health Organization recently listed snakebite envenoming as a Neglected Tropical Disease, proposing strategies to significantly reduce the global burden of this complex pathology by 2030.
Fontes, Marcos Roberto de Mattos, Fernández, Julián, Gomes, Antoniel A. S. [UNESP], Salvador, Guilherme H. M. [UNESP], Bryan Quirós, Wendy, Fernández Ulate, Julián, Lewin, Matthew R., Salvador, Guilherme Henrique Marchi, Lomonte, Bruno, Bryan-Quirós, Wendy, Gomes, Antoniel A. S., Gutiérrez, José María, Fontes, Marcos R. M. [UNESP]   +12 more
core   +6 more sources

Surfactant and Varespladib Co-Administration in Stimulated Rat Alveolar Macrophages Culture

Current Pharmaceutical Biotechnology, 2013
Acute lung injury is a life-threating condition characterized by surfactant dysfunction and raised secretory phospholipase A2 (sPLA(2)) activity.
Trias Joaquim, Gentile, Leonarda, Capoluongo E, Antonelli Massimo, Minucci, Angelo, Vendittelli, Francesca, Gentile Leonarda, Conti, Giorgio, Minucci Angelo, Conti Giorgio, De Luca, Daniele, Fraser Heather, Vendittelli Francesca, Capoluongo, Ettore Domenico, Antonelli, Massimo, Perez-Gil Jesus, De Luca Daniele   +16 more
core   +5 more sources

Hydrolysis and depletion of phosphatidylglycerol at peak murine acute lung injury [PDF]

Journal of Lipid Research
Anionic phospholipids are essential for surfactant function and phosphatidylglycerol (PG) is the most abundant. Increased secretory phospholipase A2 (sPLA2) and disproportionate depletion of PG is consistently observed in patients with acute respiratory ...
Brandon Baer, Michael C. Seeds, Michael V. Novotny, Matthew J. Satusky, Christopher M. Lloyd, Barbara Olmeda, Jesus Perez-Gil, R. Duncan Hite   +7 more
doaj   +2 more sources