Results 31 to 40 of about 1,096 (177)

Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation [PDF]

Toxicon: X
Snakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually.
Mátyás A. Bittenbinder, Eric Wachtel, Daniel Da Costa Pereira, Julien Slagboom, Nicholas R. Casewell, Paul Jennings, Jeroen Kool, Freek J. Vonk   +7 more
doaj   +7 more sources

In vitro inhibition of snake venom toxins by varespladib, marimastat, nafamostat and dimercaprol

Toxicon
Anandie le Roux, Stephanus J. Cloete, Jacobus P. Petzer, Anél Petzer   +3 more
semanticscholar   +3 more sources

Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib

Biochimie, 2022
Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. Recently, varespladib was also found to inhibit snake venom PLA2 and PLA2-like toxins.
Daniela P. Marchi‐Salvador, Êmylle Karoline Ramos Pinto, Paula Ladeira Ortolani, Consuelo Latorre Fortes-Dias, Walter Luís Garrido Cavalcante, Andreimar M. Soares, Bruno Lomonte, Matthew R. Lewin, Marcos R.M. Fontes   +8 more
semanticscholar   +6 more sources

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial [PDF]

JAMA, 2014
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes ...
Abraham, J, Abramson, B, Acheatel, R, Ahmed, M, Akhunova, S, Alegret, JM, Alonso-Pulpón, L, Amerena, J, Amkieh, A, Amlani, M, Anand, D, Anderson, J, Antolin, JM, Areses, EL, Arkhipov, M, Aroney, C, Arstall, M, Asfour, A, Ashchi, M, Auguadro, C, Azar, R, Balog, C, Banker, D, Barbarash, O, Barbarich, V, Bash, Dianna, Battaglia, J, Belenky, D, Benczur, B, BERNI, Andrea, Berti, S, Bertolet, B, Biasucci, LM, Black, R, Blanchard, A, Blonder, R, Bokern, MJ, Bosschaert, M, Braun-Dullaeus, R, Breedveld, RW, Brennan, Danielle M., Brilakis, E, Broadwater, S, Bronisz, M, Bronzwaer, PN, Brown, A, Brown, WV, Browne, K, Burtt, D, Camp, A, Cannon, K, Cavender, JB, Cavender, Matthew A., Cendon, AA, Cervinka, P, Chandna, H, Chandra, S, Chandrashekhar, Y, Chapidze, G, Chawla, K, Chernick, R, Chronos, N, Chumburidze, V, Collins, N, Constance, C, Corrada, E, Cortés, JM, Crowley, S, Csapo, K, Cuccia, C, Dabrowski, M, Dani, S, Dart, A, Davies, C, Delafontaine, P, Della-Siega, A, DeMets, D, Den Hartog, F, den Hartoog, M, Dengler, T, Denning, S, Derlaga, B, Devlin, G, Dezsi, C, Dinnyes, J, Dobrzycki, S, Doevendans, P, Dorsel, T, Dovgalevskiy, Y, Downes, T, Drenning, D, Drozdz, J, Drzewiecki, A, East, C, Eaton, G, Edes, I, Eich, D, Elliott, J, Ermoshkina, L, Esquivias, GB, Farshid, A, Faynyk, A, Fedele, F, Fernández, JD, Ferrier, L, Feskov, O, Fineschi, M, Franco, SN, French, W, Frey, N, Fulwani, M, Gebel, J, Genth-Zotz, S, Genís, AB, Gessek, J, Gielen, S, Gillespie, E, Gniot, J, Go, B, Goloborodko, B, Goloshchekin, B, González, MJ, Gordeev, I, Gormaz, CL, Gosselin, G, Goswami, R, Goya, IL, Gunalingam, B, Gupta, S, Guseva, G, Haldis, T, Haltern, G, Harding, S, Hart, H, Heckman, MJ, Hengstenberg, C, Henry, P, Hermans, W, Herrman, J, Heuer, H, Horak, D, Horowitz, J, Hubacek, J, Huff, C, Hulinsky, V, Hutyra, M, Huynh, T, Ilmer, B, Ingelmo, JM, Janik, M, Jarne, EF, Jay, D, Jukema, J. Wouter, Kahali, D, Kancz, S, Karpenko, O, Karpenko, Y, Kashou, H, Kastelein, John J. P., Katerenchuk, O, Katzan, I, Kedhi, E, Keijzers, M, Khaisheva, L, Khintibidze, I, Kie, SH, Kiss, R, Kleiman, N, Klein, G, Klimovic, T, Klimsa, Z, Kmetzo, J, Kobulia, B, Kochmanski, M, Koenig, W, Koenig, Wolfgang, Kokis, A, Kopytsya, M, Korban, E, Kornacewicz-Jach, Z, Kostenko, V, Kovacs, Z, Koval, O, Kozhukhov, S, Kozlowski, A, Kraiz, I, Kreuzer, J, Kukuy, E, Kuznetsov, V, Lago, VN, Lai, C, Lamas, G, Lambert, C, Lapp, H, Lauer, M, Lavi, S, Leithäuser, B, Lenderink, T, Leschke, M, Libis, R, Lieberman, S, Liem, A, Lincoff, A. Michael, Linev, K, Lioy, E, Lochridge, S, Lok, D, Loussararian, A, Lu, D, Lupkovics, G, MacDonald, L, Madej, A, Magagnini, E, Mahar, L, Maly, M, Mamatsashvili, M, Mann, J, Marenzi, G, Markov, V, Marso, S, Martin Mde, M, Martin, IH, Martin, L, Mayer, O, McCullum, K, Megreladze, I, Mennuni, M, Menon, Venu, Merenda, R, Merkely, B, Miekus, P, Mikhin, V, Minisi, A, Miranda, JM, Monhart, Z, Monraats, P, Montero, JS, Moretti, L, Motovska, Z, Movahed, M, Mudra, H, Mukherjee, A, Muller, G, Musial, W, Möllmann, H, Nagy, A, Nambi, Vijay, Nava, JS, Navarro, MJ, Nicholls, Stephen J., Nierop, P, Nissen,, Nogai, K, Oei, F, Ortiz, AI, Ovcharenko, E, Paradis, JM, Parikh, K, Parker, J, Peñaranda, AS, Pfeffer, M, Piscione, F, Pleva, L, Pluta, W, Polasek, P, Polgar, P, Polk, D, Pollock, S, Ponikowski, P, Prasad, C, Prati, F, Premchand, R, Prokhorov, O, Psuja, P, Pudil, R, Pérez, MB, Rajput, R, Ramaswamy, G, Rassi, A, Reichert, P, Rekosz, J, Rezkalla, S, Richardson, J, Rivera, E, Robertson, R, Rodes-Cabau, J, Roleau, J, Romero, AJ, Romo, AI, Ronaszeki, A, Ronner, E, Rosenberg, M, Rosenson, Robert S., Rotterova, H, Rubio, AM, Ruda, M, Rudenko, L, Runquist, L, Rynkiewicz, A, Sangiorgi, G, Sanmartín, M, Sanz, M, Sanz, RR, Saucedo, J, Schwartz, G, Schwartz, Gregory G., Seigel, P, Semenka, J, Senaratne, M, Sereg, M, Shaburishvili, T, Shah, A, Shalnev, V, Shishehbor, M, Shvarts, Y, Silverman, P, Simanenkov, V, Simonyi, G, Skelding, K, Soriano, FR, Speciale, G, Spinar, J, Stellbrink, C, Steven E., Hennekens C, Stillabower, M, Strain, J, Strasser, R, Sultan, P, Suriano, P, Tans, JG, Testa, R, Thadani, U, Thompson, P, Timofeev, A, Tolerico, P., Treasure, C, Trip, MD, Trivedi, S, Troquay, R, Uchino, K, Ujda, M, Urbano, RH, Vadaganelli, P, Vakaliuk, I, Valgimigli, M, van de Wetering, ML, van der Heijden, R, van Gaal, W, van Wijk, L, Veen, G, Vertes, A, Vest, A, Vijay, N, Vishnevsky, A, Voehringer, HF, Volkova, E, Wachter, R, Werner, N, White, M, Wiley, M, Wilkins, G, Williams, J, Witkowski, A, Wright, R. Scott, Wysokinski, A, Youssef, G, Zadra, R, Zateyshchikov, D, Zishiri, E, Zubiri, JJ   +369 more
core   +7 more sources

The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

Biochimica et Biophysica Acta (BBA) - General Subjects, 2021
The treatment for snakebites is early administration of antivenom, which can be highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the treatment of extra-circulatory and local effects. To complement standard-of-care treatments such as antibody-based antivenoms, natural and synthetic small molecules have been ...
Daniela P. Marchi‐Salvador, Rafael J. Borges, Bruno Lomonte, Matthew R. Lewin, Marcos R.M. Fontes   +4 more
semanticscholar   +7 more sources

Anticoagulant activity in Australasian elapid snake venoms and neutralisation with antivenom and varespladib

Toxicon
The venoms of Australasian elapid snakes are known to possess coagulant activity, including some with strong procoagulant activity and others with anticoagulant activity, although the latter are less well known. This study investigates the anticoagulant activity of Australasian elapid snake venoms, and whether this activity is neutralised by commercial
Kate Murphy, Theo Tasoulis, Nathan Dunstan, Geoffrey K. Isbister   +3 more
semanticscholar   +4 more sources

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins [PDF]

Biomedicines, 2020
Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +5 more sources

Wasp venom-induced acute kidney injury: current progress and prospects [PDF]

Renal Failure, 2023
Wasp venom can trigger local and systemic reactions, with the kidneys being commonly affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our knowledge on the underlying mechanisms of toxicity and targeted therapies ...
Fanglin Yu, Ling Wang, Hai Yuan, Zhao Gao, Li He, Fengqi Hu   +5 more
doaj   +2 more sources

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform [PDF]

Frontiers in Pharmacology, 2023
Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that
Laura-Oana Albulescu, Laura-Oana Albulescu, Adam Westhorpe, Adam Westhorpe, Rachel H. Clare, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell, Nicholas R. Casewell   +12 more
doaj   +2 more sources

The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites [PDF]

Toxins, 2019
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of 100,000 people per year. Additionally, many millions of survivors also suffer through disabilities and long-term health consequences. The only treatment for SBE,
Harry F. Williams, Harry J. Layfield, Thomas Vallance, Ketan Patel, Andrew B. Bicknell, Steven A. Trim, Sakthivel Vaiyapuri   +6 more
doaj   +3 more sources