Development of a membrane-disruption assay using phospholipid vesicles as a proxy for the detection of cellular membrane degradation [PDF]
Toxicon: XSnakebite envenoming is a global health issue that affects millions of people worldwide, and that causes morbidity rates surpassing 450,000 individuals annually.
Mátyás A. Bittenbinder +7 more
doaj +5 more sources
ToxiconThe venoms of Australasian elapid snakes are known to possess coagulant activity, including some with strong procoagulant activity and others with anticoagulant activity, although the latter are less well known. This study investigates the anticoagulant activity of Australasian elapid snake venoms, and whether this activity is neutralised by commercial
Kate Murphy +3 more
semanticscholar +4 more sources
Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins [PDF]
Biomedicines, 2020 Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie +6 more
doaj +4 more sources
Wasp venom-induced acute kidney injury: current progress and prospects [PDF]
Renal Failure, 2023 Wasp venom can trigger local and systemic reactions, with the kidneys being commonly affected, potentially causing acute kidney injury (AKI). Despite of the recent advances, our knowledge on the underlying mechanisms of toxicity and targeted therapies ...
Fanglin Yu +5 more
doaj +2 more sources
In vivo treatment with varespladib, a phospholipase A2 inhibitor, prevents the peripheral neurotoxicity and systemic disorders induced by Micrurus corallinus (coral snake) venom in rats. [PDF]
Toxicology Letters, 2021 In this study, we investigated the action of varespladib (VPL) alone or in combination with a coral snake antivenom (CAV) on the local and systemic effects induced by Micrurus corallinus venom in rats. Adult male Wistar rats were exposed to venom (1.5 mg/kg - i.m.) and immediately treated with CAV (antivenom:venom ratio 1:1.5 'v/w' - i.p.), VPL (0.5 mg/
Rosimeire Silva-Carvalho +13 more
semanticscholar +7 more sources
Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms [PDF]
Acta Pharmaceutica Sinica B, 2020 Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific ...
Chunfang Xie +6 more
doaj +4 more sources
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform [PDF]
Frontiers in Pharmacology, 2023 Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that
Laura-Oana Albulescu +12 more
doaj +2 more sources
Role of Phospholipases A2 in Vascular Relaxation and Sympatholytic Effects of Five Australian Brown Snake, Pseudonaja spp., Venoms in Rat Isolated Tissues [PDF]
Frontiers in Pharmacology, 2021 Human envenoming by Australian brown snakes (Pseudonaja spp.) may result in potentially life-threatening hypotension and subsequent cardiovascular collapse.
Nhi Thuc Vuong +2 more
doaj +2 more sources
Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms [PDF]
Molecules, 2022 Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for ...
Nicholas J. Youngman +4 more
doaj +2 more sources
The Urgent Need to Develop Novel Strategies for the Diagnosis and Treatment of Snakebites [PDF]
Toxins, 2019 Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of 100,000 people per year. Additionally, many millions of survivors also suffer through disabilities and long-term health consequences. The only treatment for SBE,
Harry F. Williams +6 more
doaj +3 more sources