Results 61 to 70 of about 949 (170)
Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020 Acute coronary syndrome (ACS) is a major cause of acute death worldwide. Both innate and adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus formation. Immune and inflammation dysfunction have been indicated in the pathogenesis of ACS.
Haiming Wang +10 more
wiley +1 more source
Diagnostic and Antivenom Immunotherapeutic Approaches in the Management of Snakebites [PDF]
, 2023 Snakebite envenoming normally occurs as a result of the injection of venom following the bite of a venomous snake or the spraying of venom into a person’s eyes by snake species that are capable of spitting venom as a defense mechanism. According to World
Gikunju, Joseph K. +2 more
core +2 more sources
Immune-mediated mechanisms of atherosclerosis and implications for the clinic. [PDF]
, 2016 A large body of evidence supports the inflammatory hypothesis of atherosclerosis, and both innate and adaptive immune responses play important roles in all disease stages.
Mallat, Ziad, Nus, Meritxell
core +1 more source
Inflammation and cardiovascular diseases: lessons from seminal clinical trials. [PDF]
, 2020 Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory cells and soluble mediators play critical roles throughout arterial plaque development and accordingly, targeting inflammatory pathways effectively reduces ...
Fabrizio Montecucco +6 more
core +1 more source
Novel snakebite therapeutics must be tested in appropriate rescue models to robustly assess their preclinical efficacy [PDF]
, 2020 In the field of antivenom research, development, and manufacture, it is often advised to follow the World Health Organization’s (WHO) guidelines for the production, control, and regulation of snake antivenom immunoglobulins, which recommend the use of ...
Ainsworth +6 more
core +3 more sources
The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming [PDF]
, 2021 A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
Abd El-Aziz, Tarek Mohamed +6 more
core +2 more sources
International Journal of Dermatology, Volume 57, Issue 5, Page 605-610, May 2018., 2018 Abstract Background Snake envenomation is a neglected global health problem. There is a need for a prehospital treatment of neurotoxic snakebite that prolongs survival and allows time for a victim to reach a hospital for antivenom therapy. Tumescent epinephrine consists of a large volume of dilute epinephrine (2 mg/l) injected subcutaneously.
Joy R. Makdisi +3 more
wiley +1 more source
Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite
Journal of Tropical Medicine, Volume 2018, Issue 1, 2018., 2018 The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge.
Tommaso C. Bulfone +4 more
wiley +1 more source
Snake Venom PLA2, a Promising Target for Broad‐Spectrum Antivenom Drug Development
BioMed Research International, Volume 2017, Issue 1, 2017., 2017 Snakebite envenomation is a neglected global health problem, causing substantial mortality, disability, and psychological morbidity, especially in rural tropical and subtropical zones. Antivenin is currently the only specific medicine for envenomation. However, it is restricted by cold storage, snakebite diagnosis, and high price.
Huixiang Xiao +5 more
wiley +1 more source
BMJ Open, 2022 Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents.
George A Wells +9 more
doaj +1 more source