Results 61 to 70 of about 1,096 (177)

Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation

Molecules, 2018
Snake venom is a complex cocktail of toxins which induces a series of clinical and pathophysiological manifestations in victims, including severe local tissue damage and systemic alterations. Deinagkistrodon acutus (D.
Huixiang Xiao, Haoran Li, Denghong Zhang, Yuanyuan Li, Shimin Sun, Chunhong Huang   +5 more
doaj   +1 more source

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? [PDF]

, 2017
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent ...
Abbas, Agca, Ait-Oufella, Albert, Alexander, Alexander, Alexander, Alexander, Andersen, Aziz, Babelova, Bellosta, Bevilacqua, Bhaskar, Blom, Boekholdt, Boekholdt, Bostrom, Brånén, Bulgarelli, Bulgarelli, Burke, Cai, Cannon, Casas, Collins, Cronstein, Dahlman-Ghozlan, Danesh, Davenport, Davey Smith, Davidson, DeOliveira, Devlin, Dinarello, Duewell, Duivenvoorden, Eisenhardt, Elango, Elhage, Ettehad, Flood, Fraser, Freigang, Fulgoni, Galkina, Galkina, Garlanda, Grassia, Grassia, Greenberg, Hansson, Hauer, Herder, Holmes, Hu, Huang, Huber, Interleukin 1 Genetics Consortium, Ivandic, Kalliolias, Kaptoge, Kimura, Kinlay, Kirii, Kleinman, Koltsova, Kureishi, Kwak, Lee, Leite, Leite, Lewington, Liao, Libby, Libby, Macritchie, Maddaluno, Maeda, Maffia, Makheja, Margaritis, McInnes, Menu, Micha, Mihaylova, Mira, Mohler, Montezano, Mulhaupt, Murad, Myasoedova, Myung, Nakata, Nicholls, O'Donoghue, Ogdie, Ohta, Pauling, Peters, Qiao, Quarck, Rajamäki, Rastogi, Reiss, Rezaie-Majd, Ridker, Ridker, Rincón, Robertson, Romano, Rosenson, Rosenson, Roubille, Ryan, Rössig, Saeed, Sage, Sarwar, Sattar, Scalia, Schett, Schieffer, Schuett, Serruys, Sever, Sever, Shah, Shaposhnik, Singh, Sirtori, Sniderman, Soedamah-Muthu, Solomon, Southan, Souverein, Sprague, Srikakulapu, Strober, Sukovich, Swerdlow, Swirski, Talmud, Tay, Teng, Thompson, Tits, Toedter, Turunen, Tzellos, Walker, Wang, Wang, Watson, Weintraub, Welsh, Welsh, Welsh, Welsh, Weng, Wensley, White, Wilensky, Willeit, Willis, Wong, Woodward, Xanthoulea, Ye, Ye, Yilmaz, Youssef, Zalewski, Zhao   +173 more
core   +2 more sources

Immune-mediated mechanisms of atherosclerosis and implications for the clinic. [PDF]

, 2016
A large body of evidence supports the inflammatory hypothesis of atherosclerosis, and both innate and adaptive immune responses play important roles in all disease stages.
Mallat, Ziad, Nus, Meritxell
core   +1 more source

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade [PDF]

, 2017
There is limited knowledge about the metabolic reprogramming induced by cancer therapies, and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K-AKT-mTOR signaling markedly decreased glycolysis and restrained
Amling, C, Cheng, L, Drake, J, Evans, M, Garg, D, Kolahi, K, Liu, J-J, Lue, H-W, Martinez-Acevedo, A, Nomura, D, O'Donnell, Valerie, Podolak, J, Rantala, J, Rao, S, Ritz, A, Thomas, G, Thornburg, K, Truillet, C, Tyner, J, Xue, C-H   +19 more
core   +2 more sources

Association between serum secretory phospholipase A2 and risk of ischaemic stroke [PDF]

, 2021
Background and purpose: Previous literature has demonstrated an association between high serum levels of type II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease.
Barlas, RS, Boekholdt, SM, Khaw, K-T, Luben, RN, Mallat, Z, Mamas, MA, Myint, PK, Smith, JW, Wareham, NJ   +8 more
core   +1 more source

Dietary Silicon Deficiency Does Not Exacerbate Diet-Induced Fatty Lesions in Female ApoE Knockout Mice. [PDF]

, 2015
BACKGROUND: Dietary silicon has been positively linked with vascular health and protection against atherosclerotic plaque formation, but the mechanism of action is unclear.
Barbara Messner, Buffoli, Burden, Buus, Carlisle, Cui, David Bernhard, Dawson, Grönros, Günther Laufer, Harris, Heinrich Schima, Hofman, Jonathan J Powell, Jugdaohsingh, Jugdaohsingh, Jugdaohsingh, Jugdaohsingh, Jugdaohsingh, Jugdaohsingh, Katharina Kessler, Kliment, Kondo, Liliana D Pedro, Lock, Loeper, Loeper, Maehira, Marque, Martin Stoiber, McCarty, Miura, Mori, Nachtigal, Najda, Natsume, Nielsen, Nishina, Parolini, Pennington, Powell, Raval, Ravin Jugdaohsingh, Renier, Santelices, Schwarz, Schwarz, Schwarz, Shaposhnik, Sripanyakorn, Sun, Tham, Trincă, Watson, Wu, Xia, Xie, Zadelaar, Zhang, Zhou   +59 more
core   +2 more sources

Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms

Molecules, 2022
Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for ...
Nicholas J. Youngman, Matthew R. Lewin, Rebecca Carter, Arno Naude, Bryan G. Fry   +4 more
doaj   +1 more source

Immune and Inflammation in Acute Coronary Syndrome: Molecular Mechanisms and Therapeutic Implications

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Acute coronary syndrome (ACS) is a major cause of acute death worldwide. Both innate and adaptive immunity regulate atherosclerosis progression, plaque stability, and thrombus formation. Immune and inflammation dysfunction have been indicated in the pathogenesis of ACS.
Haiming Wang, Zifan Liu, Junjie Shao, Lejian Lin, Min Jiang, Lin Wang, Xuechun Lu, Haomin Zhang, Yundai Chen, Ran Zhang, Jian Song   +10 more
wiley   +1 more source

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus [PDF]

, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Alsolaiss, Jaffer, Casewell, Nicholas R., Clare, Rachel H., Crittenden, Edouard, Edge, Rebecca J., Hall, Steven R., Harrison, Robert A., Kool, Jeroen, Marriott, Amy E., Menzies, Stefanie K., Westhorpe, Adam, Xie, Chunfang   +11 more
core   +6 more sources

The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms

Frontiers in Immunology, 2021
African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A2 (Group I PLA2) toxins whose activity contributes to ...
Abhinandan Chowdhury, Abhinandan Chowdhury, Matthew R. Lewin, Matthew R. Lewin, Christina N. Zdenek, Rebecca Carter, Bryan G. Fry   +6 more
doaj   +1 more source