Results 61 to 70 of about 221,092 (272)

Heuristic approaches for the car sequencing problems with block batches

EURASIP Journal on Wireless Communications and Networking, 2022
Motivated by the practical supply chain management of the automobile industry, we study the car sequencing problem (CSP) that minimizes the conflicts occur when sequentially manufacturing cars on an assembly line.
Yingjie Yu, Xiaochun Lu, Tao Zhao, Minjiao Cheng, Lin Liu, Wenchao Wei   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

An efficient General Variable Neighborhood Search for large Travelling Salesman Problem with Time Windows [PDF]

Yugoslav Journal of Operations Research, 2013
General Variable Neighborhood Search (GVNS) is shown to be a powerful and robust methodology for solving travelling salesman and vehicle routing problems.
Mladenović Nenad, Todosijević Raca, Urošević Dragan   +2 more
doaj   +1 more source

Variable Neighborhood Search for the File Transfer Scheduling Problem [PDF]

, 2012
ACM Computing Classification System (1998): I.2.8, G.1.6.In this paper a file transfer scheduling problem is considered. This problem is known to be NP-hard, and thus provides a challenging area for metaheuristics.
Dražić, Zorica
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Adaptive Variable Neighborhood Search-Based Supply Network Reconfiguration for Robustness Enhancement

Complexity, 2020
Robustness of a supply network highly depends on its structure. Although structural design methods have been proposed to create supply networks with optimal robustness, a real-life supply network can be quite different from these optimal structural ...
Ping Lou, Yuting Chen, Song Gao
doaj   +1 more source

An oil pipeline design problem [PDF]

, 2003
Copyright @ 2003 INFORMSWe consider a given set of offshore platforms and onshore wells producing known (or estimated) amounts of oil to be connected to a port.
Aarts E. H. L., Bertelè U., Brimberg J., Chu Y., Hansen P., Jack Brimberg, Keh-Wei Lin, MichÈle Breton, Minoux M., Minoux M., Mladenović N., Nemhauser G. L., Nenad Mladenović, Pierre Hansen   +13 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Solving the Task Assignment Problem with a Variable Neighborhood Search [PDF]

, 2010
In this paper a variable neighborhood search (VNS) approach for the task assignment problem (TAP) is considered. An appropriate neighborhood scheme along with a shaking operator and local search procedure are constructed specifically for this problem ...
Filipović, Vladimir, Kratica, Jozef, Milanović, Marija, Savić, Aleksandar   +3 more
core  

Pengembangan Algoritma Hybrid Restart Simulated Annealing with Variable Neighborhood Search (HRSA-VNS) Untuk Penyelesaian Kasus Vehicle Routing Problem with TIME Windows (VRPTW) [PDF]

, 2017
Determining the vehicle routing is one of the important components in existing logistics systems. It is because the vehicle route problem has some effect on transportation costs and time required in the logistics system. In determining the vehicle routes,
Iswari, T. (Titi)
core   +2 more sources