Results 51 to 60 of about 4,234 (154)

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.

PLoS ONE, 2013
Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci.
Carlos Cordon-Obras, Jorge Cano, Dolores González-Pacanowska, Agustin Benito, Miguel Navarro, Jean-Mathieu Bart   +5 more
doaj   +1 more source

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections:a feint attack by parasites [PDF]

, 2018
The parasitic African trypanosome, Trypanosoma brucei, evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs).
A Beschin, A Fadda, A Schwede, AP Jackson, C Hertz-Fowler, D Horn, E Gjini, G Caljon, GA Cross, H Fairbairn, HT Timmers, JD Barry, JJ Doyle, JP Hall, K Sheader, KA Lythgoe, L Glover, L Marcello, L Sullivan, M Berriman, M Recker, M Recker, MK Higgins, MR Mugnier, PL Johnson, PT Manna, RL Barnes, S Trindade, SA Frank, SA Frank, WL Dempsey, Z Agur   +31 more
core   +2 more sources

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Arieli Bernardo Portugal, Renato Augusto DaMatta, Edézio Ferreira da Cunha Júnior, João Luiz Mendes Wanderley   +3 more
wiley   +1 more source

Expression profiling of Trypanosoma congolense genes during development in the tsetse fly vector Glossina morsitans morsitans

Parasites & Vectors, 2018
Background The tsetse transmitted parasitic flagellate Trypanosoma congolense causes animal African trypanosomosis (AAT) across sub-Saharan Africa. AAT negatively impacts agricultural, economic, nutritional and subsequently, health status of the affected
Erick O. Awuoche, Brian L. Weiss, Paul O. Mireji, Aurélien Vigneron, Benson Nyambega, Grace Murilla, Serap Aksoy   +6 more
doaj   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Insight into the exoproteome of the tissue-derived trypomastigote form of trypanosoma cruzi [PDF]

, 2016
The protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cell. The secreted/excreted protein repertoire released by T.
Bastos, Izabela M D, Charneau, Sébastien, de Santana, Jaime M, de Sousa, Marcelo V, Machado, Mara O, Queiroz, Rayner M L, Ricart, Carlos A O, Roepstorff, Peter   +7 more
core   +3 more sources

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. [PDF]

, 1980
We have isolated poly(A)+ RNA from four antigenic variants (117, 118, 121, 221) of one clone of Trypanosoma brucei. Translation of these poly(A)+ RNAs in a rabbit reticulocyte lysate gave rise to proteins that could be precipitated with antisera against ...
Borst, P. (Piet), Burg, J. van den, Cross, G.A.M., Hoeijmakers, J.H.J. (Jan), Weissmann, C.   +4 more
core   +2 more sources

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, Volume 49, Issue 11, Page 1395-1410, November 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source