Results 61 to 70 of about 4,234 (154)

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics [PDF]

, 2012
Trypanosoma brucei survives in mammals through antigenic variation, which is driven by RAD51-directed homologous recombination of Variant Surface Glycoproteins (VSG) genes, most of which reside in a subtelomeric repository of >1000 silent genes. A key
Alsford, Anna Trenaman, Ayoub, Becker, Bennett, Bork, Bringaud, Brough, Callejas, Carlos R. Machado, Carreira, Carreira, Chung, Claire Hartley, Danielle G. Passos-Silva, Daniels, Davies, Davies, Dobson, Dray, Dumont, Esashi, Esashi, Futamura, Genois, Giloni, Glover, Hartley, Hashimoto, Heyer, Jackson, Jeyasekharan, Kim, Kim, Ko, Kojic, Kojic, Kojic, Lee, Lisby, Lo, Lord, Marcello, Marko Prorocic, Marmorstein, McCulloch, McKean, McKean, Melville, Mizuta, Moniek van den Hoek, Morrison, Munday, Oyola, Park, Petalcorin, Proudfoot, Raz, Regis-da-Silva, Renzette, Richard McCulloch, Robinson, Saeki, Schlacher, Shivji, Tarsounas, Tarsounas, Vink, Volodymyr Nechyporuk-Zloy, Yu, Zeiner, Zhou   +71 more
core   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Trypanosome mRNAs share a common 5' spliced leader sequence. [PDF]

, 1984
A 5'-terminal leader sequence of 35 nucleotides was found to be present on multiple trypanosome RNAs. Based on its representation in cDNA libraries, we estimate that many, if not all, trypanosome mRNAs contain this leader. This same leader was originally
Agabian, N, Nelson, RG, Parsons, M, Watkins, KP   +3 more
core  

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei [PDF]

, 2020
BACKGROUND Vacuolar H-ATPase (V-ATPase) is a highly conserved protein complex which hydrolyzes ATP and pumps protons to acidify vacuolar vesicles.
Hide, G, Lai, D-H, Li, F-J, Lun, Z-R, Xu, Z-S   +4 more
core   +2 more sources

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific [PDF]

, 2007
Background: In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...

core   +1 more source

Phosphatase activity characterization on the surface of intact bloodstream forms of Trypanosoma brucei [PDF]

, 2003
Procyclic forms of Trypanosoma brucei possess a phosphatase activity on their external cell surface. This activity, while it dephosphorylates [P-32]phosphocasein, is inhibited weakly by NaF and tartrate but strongly by vanadate. in this work, we describe
Aoyama, Hiroshi, Fernandes, Eloise Cedro, Granjeiro, José Mauro, Meyer-Fernandes, José Roberto, Taga, Eulázio Mikio   +4 more
core   +2 more sources

Comparative Genomic Analysis of Co‐Occurring Hybrid Zones of House Mouse Parasites Pneumocystis murina and Syphacia obvelata Using Genome Polarisation

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT Parasites are expected to hybridise in similar ways to free‐living organisms, although this may be modified by their reduced genome architecture. Recombinant strains and taxa of hybrid origin can be studied in nature where hosts come into secondary contact. Here we apply genome‐wide analysis to parasites from a contact previously characterised
Jan Petružela, Beate Nürnberger, Alexis Ribas, Georgios Koutsovoulos, Dagmar Čížková, Alena Fornůsková, Tatiana Aghová, Mark Blaxter, Joëlle Goüy de Bellocq, Stuart J. E. Baird   +9 more
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro [PDF]

, 2013
Parasite infections are largely dependent on interactions between pathogen and different host cell populations to guarantee a successful infectious process.
Alves, Maria Julia Manso, Colli, Walter, Tonelli, Renata Rosito   +2 more
core   +2 more sources

Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper

Ecology and Evolution, Volume 15, Issue 9, September 2025.
Introduced pathogens exert novel selection on hosts, and some hosts have adapted to highly virulent pathogens. We tested for differential gene expression between (i) avian malaria‐infected and ‐uninfected Hawai'i 'amakihi and (ii) low‐ and high‐elevation 'amakihi.
Loren Cassin‐Sackett, Katherine M. McClure, Taylor E. Callicrate, Eben H. Paxton, Robert C. Fleischer   +4 more
wiley   +1 more source