Results 131 to 140 of about 1,572,926 (319)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

HD-and-RNA-variants-Chr12.vcf

, 2017
All HD and RNAseq variants on chromosome 12.
Thomas Lopdell (511314), Russell Snell (387740), Davis, Steve, Christine Couldrey (169434), Maksim Struchalin (166855), Steve Davis (5017841), Kathryn Tiplady (511313), Littlejohn, Mathew, Couldrey, Christine, Spelman, Richard, Struchalin, Maksim, Thomas Johnson (363281), Ric Sherlock (511317), Mathew Littlejohn (4690033), Tiplady, Kathryn, Sherlock, Ric, Richard Spelman (387738), Lopdell, Thomas, Johnson, Thomas, Keehan, Michael, Michael Keehan (4690036), Snell, Russell   +21 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

HD-and-RNA-variants-Chr17.vcf

, 2017
All HD and RNAseq variants on chromosome 17.
Thomas Lopdell (511314), Russell Snell (387740), Davis, Steve, Christine Couldrey (169434), Maksim Struchalin (166855), Steve Davis (5017841), Kathryn Tiplady (511313), Littlejohn, Mathew, Couldrey, Christine, Spelman, Richard, Struchalin, Maksim, Thomas Johnson (363281), Ric Sherlock (511317), Mathew Littlejohn (4690033), Tiplady, Kathryn, Sherlock, Ric, Richard Spelman (387738), Lopdell, Thomas, Johnson, Thomas, Keehan, Michael, Michael Keehan (4690036), Snell, Russell   +21 more
core   +1 more source

Variant Explosion [PDF]

BioTechniques, 2012
openaire   +3 more sources

Myoglobin variants [PDF]

Biochemical Journal, 1970
R E, Boulton, R G, Huntsman, H, Lehmann, P, Lorkin, A E, Romero-Herrera   +4 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

HD-and-RNA-variants-Chr5.vcf

, 2017
All HD and RNAseq variants on chromosome 5.
Thomas Lopdell (511314), Russell Snell (387740), Davis, Steve, Christine Couldrey (169434), Maksim Struchalin (166855), Steve Davis (5017841), Kathryn Tiplady (511313), Littlejohn, Mathew, Couldrey, Christine, Spelman, Richard, Struchalin, Maksim, Thomas Johnson (363281), Ric Sherlock (511317), Mathew Littlejohn (4690033), Tiplady, Kathryn, Sherlock, Ric, Richard Spelman (387738), Lopdell, Thomas, Johnson, Thomas, Keehan, Michael, Michael Keehan (4690036), Snell, Russell   +21 more
core   +1 more source

Comprehensive Screening of Genetic Variants in the Coding Region of F8 in Severe Hemophilia A Reveals a Relationship with Disease Severity in a Colombian Cohort

Life
Hemophilia A is an X-linked disorder characterized by quantitative deficiency of coagulation factor VIII (FVIII) caused by pathogenic variants in the factor 8 (F8) gene.
Samuel Sarmiento Doncel, Ronald Guillermo Peláez, Pablo Lapunzina, Fernando F. Corrales-Medina, Gina Alejandra Díaz Mosquera, Santiago Bonanad, Javier Mauricio Cortes, Mario Cazalla, Natalia Gallego, Felipe Querol-Giner, Jair Tenorio, José A. López Guerrero   +11 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source