Results 131 to 140 of about 1,388,843 (289)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Diversity of gliadins and HMW glutenin subunits in Czech registered wheat varieties
Czech Journal of Genetics and Plant Breeding, 2005 J. Bradová, A. Šašek
doaj +1 more source
Ecotoxicology and Environmental SafetyHeavy metal(loid)s (HMs) represent significant environmental and health threats due to their persistence, bioaccumulation, and ability to induce oxidative stress and lipid peroxidation (LPO) in aquatic organisms.
Waqas Waqas +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
WHEAT GENETIC RESOURCES IN KYRGYZSTAN
Вавиловский журнал генетики и селекции, 2014 Botanical and ecological study of material collected in different areas of Kyrgyzstan showed a broad variability of ecological and morphological forms in wheat landraces. A total of 60 subspecies of spring wheat belonging to 6 species were found. Several
M. Dzhunusova, D. Ten, N. Aubekerova
doaj
HorticulturaeEnvironmental temperature significantly affects plant growth and development, particularly flower development. In pepper (Capsicum annuum), the molecular mechanisms underlying temperature-mediated floral organ development remain unclear.
Yin Luo +10 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Genome-Wide Dissection of Selection on microRNA Target Genes Involved in Rice Flower Development
PlantsAlthough genome-wide studies have identified a number of candidate regions evolving under selection in domesticated animals and cultivated plants, few attempts have been made, from the point of a definite biological process, to assess sequence variation ...
Fen Zhang, Li-Zhen Ling, Li-Zhi Gao
doaj +1 more source