Results 51 to 60 of about 14,417 (236)
Congruences of Galois representations attached to effective $A$-motives over global function fields
, 2023 This article investigates congruences of $\mathfrak{p}$-adic representations arising from effective $A$-motives defined over a global function field $K$.
Okumura, Yoshiaki
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the Brauer–Siegel ratio for abelian varieties over function fields
, 2019 Hindry has proposed an analog of the classical Brauer–Siegel theorem for abelian varieties over global fields. Roughly speaking, it says that the product of the regulator of the Mordell–Weil group and the order of the Tate–Shafarevich group should have ...
Ulmer, Douglas
core +1 more source
Negotiating cultures of work in transnational law firms. [PDF]
, 2008 The geographical strategies of transnational corporations have received extensive attention from economic geographers. A particularly important line of study has focused upon the diverse national institutions that create geographically heterogeneous ...
Faulconbridge, James R. +1 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Journal of Algebra, 1987 Let A be the coordinate ring of a nonsingular affine variety over an algebraically closed field of characteristic \(p>0.\) It is proved that \(gl.\dim (D(A))=\dim (A)\) where D(A) is the ring of differential operators on A. In characteristic zero the result was known [cf. \textit{S. U. Chase}, Commun. Algebra 1, 351-363 (1974; Zbl 0315.13011)].
openaire +2 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source