Viruses, 2016 In 2007, the United States– Food and Drug Administration (FDA) issued guidance concerning animal models for testing the efficacy of medical countermeasures against variola virus (VARV), the etiologic agent for smallpox.
Jennifer Garver +7 more
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Expression and functional characterisation of Variola and Monkeypox virus tumour necrosis factor receptor (TNFR) proteins [PDF]
, 2012 University of Technology, Sydney. Faculty of Science.Tumour necrosis factor-a (TNFα) is a pleiotropic cytokine that plays a critical role in cellular response to virus infection. Virtually all poxviruses encode genes that are homologous to human tumour
Sherwood, S
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Ankyrin-like proteins of variola and vaccinia viruses [PDF]
, 1993 Computer analysis of full coding sequences of variola major virus strain India-1967 genome and vaccinia virus strain Copenhagen genome have been carried out.
Lev S. Sandakhchiev +5 more
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Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records. [PDF]
Microb Genom, 2023 Forni D +4 more
europepmc +1 more source
In vitro characterization of a nineteenth-century therapy for smallpox.
PLoS ONE, 2012 In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections.
William Arndt +9 more
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Virus biosafety and biodefense category list comparison.
, 2014 aSmallpox is caused by Variola viruses. Variola viruses including Variola major which causes disease with serious clinical symptoms and Variola minor (alastrim) which causes disease with less severe clinical symptoms.
Deqiao Tian (590816), Tao Zheng (146941)
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The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. [PDF]
, 2011 The influenza A virus RNA polymerase is a heterotrimeric complex responsible for viral genome transcription and replication in the nucleus of infected cells. We recently carried out a proteomic analysis of purified polymerase expressed in human cells and
Juan Ortín +15 more
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In Silico Studies of Potential Selective Inhibitors of Thymidylate Kinase from Variola virus. [PDF]
Pharmaceuticals (Basel), 2021 Garcia DR +7 more
europepmc +1 more source
Poxvirus Viability and Signatures in Historical Relics
Emerging Infectious Diseases, 2014 Although it has been >30 years since the eradication of smallpox, the unearthing of well-preserved tissue material in which the virus may reside has called into question the viability of variola virus decades or centuries after its original occurrence ...
Andrea M. McCollum +7 more
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Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes [PDF]
, 2007 Topoisomerase enzymes regulate superhelical tension in DNA resulting from transcription, replication, repair, and other molecular transactions. Poxviruses encode an unusual type IB topoisomerase that acts only at conserved DNA sequences containing the ...
Lefkowitz, Elliot J. +7 more
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