Results 81 to 90 of about 1,046,980 (206)
MedComm, Volume 7, Issue 7, July 2026.High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai +10 more
wiley +1 more source
Report of the World Health Organization (WHO) Biosafety Inspection Team of the Variola Virus Maximum Containment Laboratories to the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, United States of America, 8-12 May 2017 [PDF]
The WHO team of international experts carried out a biosafety inspection at one of the two WHO- authorized variola virus (causative agent of smallpox) repositories: CDC*, in May 2017 in accordance with World Health Assembly resolution WHA60.1 (2007 ...
core
Cancer Science, Volume 117, Issue 7, Page 2007-2020, July 2026.OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan +8 more
wiley +1 more source
PLoS Pathogens, 2015 Orthopoxviruses (OPV), including variola, vaccinia, monkeypox, cowpox and ectromelia viruses cause acute infections in their hosts. With the exception of variola virus (VARV), the etiological agent of smallpox, other OPV have been reported to persist in ...
Isaac G Sakala +6 more
doaj +1 more source
Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism
Advances in Virology, 2012 In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism ...
Sergei N. Shchelkunov
doaj +1 more source
Thermo-Efficient Strains of Variola Major Virus
Journal of General Virology, 1967 Thermo-efficient and thermo-sensitive mutants of pox viruses are obtained, without the aid of mutagens, only with difficulty. Kirn and his colleagues (1, 2) have described both a thermo-sensitive and a thermo-efficient mutant of vaccinia virus. This note reports the derivation and properties of two thermo-efficient strains of variola major virus.
K R, Dumbell, H S, Bedson, M, Nizamuddin
openaire +2 more sources
Variola virus infection in Vero E6 cells at different MOI at 24 hours post infection.
, 2015 Cell images were collected at 5X magnification with 9 fields per well. Variola virus (Solaimen) was titrated at different MOI concentrations. Wells with uninfected control cells were included on each plate to be used for gating purposes during image ...
Victoria Olson (210647) +5 more
core +1 more source
Salud Pública de México, 2003 Uno de los grandes logros de la salud pública mundial, la erradicación de la viruela, puede verse mermado por el posible riesgo de bioterrorismo. El debate acerca de la destrucción de los restos del virus en los dos laboratorios de referencia de la ...
Carlos Franco-Paredes +5 more
doaj
Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +1 more source
Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms [PDF]
, 1993 Analysis of variola virus nucleotide sequence revealed proteins belonging to several families which provide the virus with the possibility of overcoming the barriers of specific and non-specific host defence against viral infection.
Lev S. Sandakhchiev +5 more
core +1 more source