Results 81 to 90 of about 1,368,656 (159)

Smallpox Still Haunts Scientists: Results of a Questionnaire-Based Inquiry on the Views of Health Care and Life Science Experts and Students on Preserving the Remaining Variola Virus Stocks

The Scientific World Journal, 2013
The World Health Organization (WHO) declared eradication of the dreadful disease “smallpox” in 1980. Though the disease has died down, the causative virus “variola” has not, as it has been well preserved in two high security laboratories—one in USA and ...
Thangavelu Srinivasan, Vidyasagar Devaprasad Dedeepiya, Sudhakar John, Rajappa Senthilkumar, Helen C. Reena, Paramasivam Rajendran, Madasamy Balamurugan, Gene Kurosawa, Masaru Iwasaki, Senthilkumar Preethy, Samuel J. K. Abraham   +10 more
doaj   +1 more source

SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine-binding proteins family

BMC Research Notes, 2010
Background Variola virus (VARV) the causative agent of smallpox, eradicated in 1980, have wide spectrum of immunomodulatory proteins to evade host immunity.
Shchelkunov Sergei N, Nepomnyashchikh Tatyana S, Antonets Denis V   +2 more
doaj   +1 more source

Enfrentando el bioterrorismo: aspectos epidemiológicos, clínicos y preventivos de la viruela Confronting bioterrorism: epidemiologic, clinical, and preventive aspects of smallpox

Salud Pública de México, 2003
Uno de los grandes logros de la salud pública mundial, la erradicación de la viruela, puede verse mermado por el posible riesgo de bioterrorismo. El debate acerca de la destrucción de los restos del virus en los dos laboratorios de referencia de la ...
Carlos Franco-Paredes, Carlos del Río, Margarita Nava-Frías, Sigfrido Rangel-Frausto, Ildefonso Téllez, José Ignacio Santos-Preciado   +5 more
doaj  

WHO Advisory Committee on Variola Virus Research: report of the twenty-sixth meeting, Geneva, Switzerland, 13-14 November 2024 [PDF]

vii, 34, [24] p.This report summarizes the proceedings, research updates and recommendations of the twenty-sixth meeting of the WHO Advisory Committee on Variola Virus Research, held in Geneva on 13–14 November 2024.
World Health Organization
core  

Ectromelia Virus Disease Characterization in the BALB/c Mouse: A Surrogate Model for Assessment of Smallpox Medical Countermeasures

Viruses, 2016
In 2007, the United States– Food and Drug Administration (FDA) issued guidance concerning animal models for testing the efficacy of medical countermeasures against variola virus (VARV), the etiologic agent for smallpox.
Jennifer Garver, Lauren Weber, Eric M. Vela, Mike Anderson, Richard Warren, Michael Merchlinsky, Christopher Houchens, James V. Rogers   +7 more
doaj   +1 more source

Teaching a new mouse old tricks: Humanized mice as an infection model for Variola virus. [PDF]

PLoS Pathog, 2021
Hutson CL, Kondas AV, Ritter JM, Reed Z, Ostergaard SD, Morgan CN, Gallardo-Romero N, Tansey C, Mauldin MR, Salzer JS, Hughes CM, Goldsmith CS, Carroll D, Olson VA.   +13 more
europepmc   +1 more source

Evidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Naïve Mice.

PLoS Pathogens, 2015
Orthopoxviruses (OPV), including variola, vaccinia, monkeypox, cowpox and ectromelia viruses cause acute infections in their hosts. With the exception of variola virus (VARV), the etiological agent of smallpox, other OPV have been reported to persist in ...
Isaac G Sakala, Geeta Chaudhri, Anthony A Scalzo, Preethi Eldi, Timothy P Newsome, Robert M Buller, Gunasegaran Karupiah   +6 more
doaj   +1 more source

Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism

Advances in Virology, 2012
In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism ...
Sergei N. Shchelkunov
doaj   +1 more source

Detection of variola virus infection using molecular techniques.

A-B) Variola virus (VARV) antigen (brown in A) and RNA (red in B) were detected in the haired skin of NHP #13, a placebo-treated cynomolgus macaque that succumbed to VARV exposure; immunohistochemistry (IHC) and RNA in situ hybridization (ISH ...
Dennis E. Hruby (17691646), Todd M. Bell (12072418), Jo Lynne Raymond (10073931), Paul Facemire (12072421), Janice A. Williams (6842360), Arthur J. Goff (11067983), Jeremy J. Bearss (18010652), Inger K. Damon (18010655), Jennifer Chapman (506139), Joshua D. Shamblin (9010217), Douglas W. Grosenbach (17691652), Xiankun Zeng (623049), Eric M. Mucker (13788577)   +12 more
core   +1 more source

Biological threat preparedness through vaccine development and stockpiling: challenges and strategic implications

Frontiers in Public Health
Biological threat agents such as Bacillus anthracis, Variola virus, and botulinum toxin pose serious risk to national security and public health due to their high transmissibility, lethality, and potential for weaponization.
Jungeun Lee
doaj   +1 more source