Results 71 to 80 of about 3,764,275 (310)

Vascular Dementia [PDF]

Current Translational Geriatrics and Experimental Gerontology Reports, 2013
The purpose of this review is to highlight existing literature on the epidemiology, pathophysiology, and novel risk factors for vascular dementia. We further examine the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular diseases to the development of vascular dementia.
Alberto R, Ramos, Salim I, Dib, Clinton B, Wright   +2 more
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Surgeon Speaks-Paul J. DiMuzio, MD, FACS [PDF]

, 2014
“Patients with extensive acute deep vein thrombosis (DVT) of the legs provide an excellent example of why effective medical-surgical collaboration is so important.

core   +1 more source

A cross-sectional study of vascular risk factors in a rural South African population : data from the Southern African Stroke Prevention Initiative (SASPI) [PDF]

, 2007
Background: Rural sub-Saharan Africa is at an early stage of economic and health transition. It is predicted that the 21st century will see a serious added economic burden from non-communicable disease including vascular disease in low-income countries
A Lee, ABM Swai, C Bunker, CA. Monteiro, CJL Murray, DM Reed, F Cappuccio, FGR Fowkes, FP Cappuccio, Gerry Fowkes, Gillian Lewando Hundt, GMB Berger, HS Kruger, JA Schellenberg, JC Mbanya, Jennifer Marsh, JS Kaufman, K Kahn, K Kahn, K Kahn, K Kahn, K Kahn, K Steyn, M Thorogood, Margaret Thorogood, MD Connor, ME Edginton, Medical Research Council, Myles Connor, National Heart Lung and Blood Institute, R Cooper, R Edwards, R Walker, RF Gillum, RW Walker, S Kerry, S Leeder, S Yusuf, SASPI Team, SASPI Team, SASPI Team, SM Tollman, Stephen Tollman, T Puoane, TA Pearson, W Oosthuizen, WF Mollentze, World Health Organisation, World Health Organisation   +48 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells [PDF]

, 2008
Purinergic signalling is important both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling.
Burnstock, G
core  

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension

Pharmaceuticals, 2009
Soluble epoxide hydrolase inhibitors (sEHIs) are demonstrating promise as potential pharmaceutical agents for the treatment of cardiovascular disease, diabetes, inflammation, and kidney disease. The present study determined the ability of a first-inclass
Sean Shaw, John D. Imig, Margaret A. Carpenter   +2 more
doaj   +1 more source

Morphological and morphometrical aspects of intima and media of the common, external and internal iliac arteries in Chinchilla lanigera (Rodentia, Chinchillidae) bred in captivity

The European Zoological Journal, 2020
The paper approaches deal with fine differential morphological and morphometrical aspects of the structure of three main blood vessels in Chinchilla lanigera: the common iliac artery, the internal iliac artery and the external iliac artery.
C. O. Martonos, A. Damian, G. Alexandru, M. Viorel, V. Rus, F. G. Stan   +5 more
doaj   +1 more source