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Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
Vasa - European Journal of Vascular Medicine, 2022Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3 (AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic properties. VAP-1 is a primary amine oxidase belonging to the semicarbazide-sensitive amine oxidase (SSAO) family, which catalyzes the oxidation of primary amines leading to the production ...
Marianna Danielli +2 more
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Vascular adhesion protein-1 and microvascular diabetic complications
Pharmacological Reports, 2022Vascular adhesion protein-1 (VAP-1) is a bifunctional protein that has the ability to catalyze the deamination of primary amines and is involved in the production of hydrogen peroxide, aldehydes, and advanced glycation end products (AGEs). VAP-1 is usually stored in intracellular vesicles of endothelial cells, smooth muscles, and adipocytes.
Alok D. Singh, Yogesh A. Kulkarni
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A new crystal form of human vascular adhesion protein 1 [PDF]
Acta Crystallographica Section F: Structural Biology Communications, 2010 Human vascular adhesion protein 1 (VAP-1) is involved in lymphocyte-endothelial cell adhesion and has been implicated in many human inflammatory diseases. VAP-1 is a member of the copper amine oxidase family of enzymes with a trihydroxyphenylalanine quinone (TPQ) cofactor.
Aaron P Mcgrath +2 more
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Expression of Vascular Adhesion Protein-1 in Atopic Eczema
International Archives of Allergy and Immunology, 2006<i>Background:</i>Vascular adhesion protein-1 (VAP-1) is an adhesion molecule with an enzymatic activity which partakes in the migration process of lymphocytes. The aim of this study was to investigate VAP-1 expression in atopic eczema (AE) in comparison with healthy controls and psoriatic individuals.
Aneta, Madej +3 more
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Lymphocyte Trafficking Mediated by Vascular Adhesion Protein-1 [PDF]
Circulation Research, 2000 The trafficking, extravasation, and retention of lymphocytes within certain tissues (eg, lymph nodes) seem to be mediated by several classes of specialized adhesion glycoproteins that are expressed on the surface of unique endothelial cells (high endothelial venules [HEVs]) that exist in both the blood and lymph microvessels.1 2 The binding of these ...
J Steve Alexander, D Neil Granger
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Hepatic consequences of vascular adhesion protein-1 expression
Journal of Neural Transmission, 2011The liver is constantly exposed to antigens present in the blood and to particulate antigens delivered from the gut. To maintain effective levels of immune surveillance and yet tolerate food antigens, the hepatic environment has become highly specialised.
Chris J, Weston, David H, Adams
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Vascular adhesion protein‐1 in human ischaemic stroke
Neuropathology and Applied Neurobiology, 2008Aims: Leukocyte extravasation exacerbates tissue injury after ischaemic stroke. Vascular adhesion protein‐1 (VAP‐1) is an endothelial adhesion molecule with the potential capacity to guide transmigration of inflammatory cells into ischaemic brain. Moreover, VAP‐1 could worsen ischaemic brain injury due to its function as a semicarbazide‐sensitive ...
L, Airas +6 more
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Vascular adhesion protein‐1 and syndecan‐1 in septic shock
Acta Anaesthesiologica Scandinavica, 2011BackgroundConstituents of vascular endothelial surface layer (glycocalyx), e.g. an anchor protein syndecan‐1 (SDC‐1), can be detected in plasma in many inflammatory conditions. In inflammation, vascular adhesion protein‐1 (VAP‐1) is rapidly translocated to the apical side of the endothelial cells and may be released to plasma in a soluble form.
Pettilä Ville +4 more
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A mouse molecular mimic of human vascular adhesion protein-1
Molecular Immunology, 1997Human vascular adhesion protein-1 (VAP-1) is an endothelial sialoglycoprotein which exists in forms of Mr 90000 and 170000 and mediates lymphocyte binding to vessels under shear. VAP-1 is functionally defined by an inhibitory mouse mAb 1B2. A large-scale immunoaffinity purification of VAP-1 from human tonsil lysates was performed to determine the ...
M, Salmi +6 more
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Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients
Journal of the American Society of Hypertension, 2015The aim of the study was to estimate and correlate circulating levels of renalase, vascular adhesion protein-1 (VAP-1), catecholamines in patients with primary hypertension. The renalase, VAP-1, and catecholamines concentration was estimated in 121 hypertensive patients.
Dominika, Maciorkowska +2 more
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