Results 261 to 270 of about 443,542 (283)

Vascular adhesion protein-1 (VAP-1)

2007
In 1980s the leukocyte adhesion molecules and their ligands on the vascular endothelium were thought to explain tissue-selective, or even tissue-specific, leukocyte traffic. At the same time it became apparent that vessels in inflamed joints displayed binding characteristics clearly distinct from those in peripheral lymph nodes, gut and skin. In search
Marko Salmi, Sirpa Jalkanen
openaire   +1 more source

Overexpression of vascular adhesion protein‐1 is associated with poor prognosis of astrocytomas

Apmis, 2016
Vascular adhesion protein‐1 (VAP‐1) is one of the endothelial adhesion molecules that is believed to play a role in tumor progression and metastasis, supporting cancer cell extravasation. Very few studies have been performed on analyzing the contribution of VAP‐1 in brain tumor.
Shu-Jyuan Chang, Chun-Chieh Wu, Chee-Yin Chai   +2 more
exaly   +3 more sources

Organ‐selective regulation of vascular adhesion protein‐1 expression in man

European Journal of Immunology, 1997
AbstractVascular adhesion protein‐1 (VAP‐1) is an endothelial molecule which mediates lymphocyte binding to endothelium in peripheral lymph nodes and at certain sites of inflammation. The expression of VAP‐1 in vivo is strongly up‐regulated in inflamed tissues, such as gut and skin.
A M, Arvilommi, M, Salmi, S, Jalkanen
openaire   +2 more sources

Vascular adhesion protein‐1 (VAP‐1) is overexpressed in psoriatic patients

Journal of the European Academy of Dermatology and Venereology, 2006
AbstractBackground  Vascular adhesion protein (VAP)‐1 is an adhesion molecule with an enzymatic activity that partakes in the migration process of lymphocytes.Objectives  The aim of this study was to investigate the expression of VAP‐1 in the skin and serum of psoriatic patients.Material and methods  Seventy‐one patients suffering from psoriasis aged ...
A, Madej, A, Reich, A, Orda, J C, Szepietowski   +3 more
openaire   +2 more sources

Inhibition of vascular adhesion protein‐1 suppresses endotoxin‐induced uveitis

The FASEB Journal, 2007
Inflammatory leukocyte accumulation is a common feature of major ocular diseases, such as uveitis, diabetic retinopathy, and age‐related macular degeneration. Vascular adhesion protein‐1 (VAP‐1), a cell surface and soluble molecule that possesses semi‐carbazide‐sensitive amine oxidase (SSAO) activity, is involved in leukocyte ...
Kousuke, Noda, Shinsuke, Miyahara, Toru, Nakazawa, Lama, Almulki, Shintaro, Nakao, Toshio, Hisatomi, Haicheng, She, Kennard L, Thomas, Rebecca C, Garland, Joan W, Miller, Evangelos S, Gragoudas, Yosuke, Kawai, Yukihiko, Mashima, Ali, Hafezi-Moghadam   +13 more
openaire   +2 more sources

Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

Clinica Chimica Acta, 2009
The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes.Adults without history
Hung-Yuan Li, Jung-Nan Wei, Mao-Shin Lin, David J. Smith, Jani Vainio, Cheng-Hsin Line, Fu-Tien Chiang, Shyang-Rong Shih, Ching-Huei Huang, Mei-Yu Wu, Yenh-Chen Hsein, Lee-Ming Chuang   +11 more
openaire   +3 more sources

Vascular Adhesion Protein‐1 as a Potential Therapeutic Target in Liver Disease

Annals of the New York Academy of Sciences, 2007
Abstract:  Vascular adhesion protein‐1 (VAP‐1) is a homodimeric, transmembrane sialoglycoprotein, and amine‐oxidase enzyme constitutively expressed by hepatic endothelial cells, and as a soluble protein in serum (sVAP‐1). VAP‐1 mediates leukocyte adhesion and migration in an enzyme activity‐dependent manner.
Patricia F, Lalor, Ceren, Tuncer, Chris, Weston, Azucena, Martin-Santos, David J, Smith, David H, Adams   +5 more
openaire   +2 more sources

Vascular adhesion protein-1: Role in human pathology and application as a biomarker

Critical Reviews in Clinical Laboratory Sciences, 2015
Vascular adhesion protein-1 (VAP-1) is a member of the copper-containing amine oxidase/semicarbazide-sensitive amine oxidase (AOC/SSAO) enzyme family. SSAO enzymes catalyze oxidative deamination of primary amines, which results in the production of the corresponding aldehyde, hydrogen peroxide and ammonium.
Roos, Pannecoeck, Daphne, Serruys, Lara, Benmeridja, Joris R, Delanghe, Nanja, van Geel, Reinhart, Speeckaert, Marijn M, Speeckaert   +6 more
openaire   +2 more sources

Targeting Vascular Adhesion Protein‐1 to Treat Autoimmune and Inflammatory Diseases

Annals of the New York Academy of Sciences, 2007
Abstract:  The development of new, safe, and effective anti‐inflammatory drugs represents a major challenge for the pharmaceutical industry, as well as a significant opportunity. The increasing prevalence of chronic inflammatory and autoimmune diseases associated with an aging population has led to an intense effort to discover new anti‐inflammatory ...
David J, Smith, Petri J, Vainio
openaire   +2 more sources

Developmental regulation of the adhesive and enzymatic activity of vascular adhesion protein-1 (VAP-1) in humans

Blood, 2006
Vascular adhesion protein-1 (VAP-1) is a homodimeric glycoprotein that belongs to a unique subgroup of cell-surface-expressed oxidases. In adults, endothelial VAP-1 supports leukocyte rolling, firm adhesion, and transmigration in both enzyme activity-dependent and enzyme activity-independent manner.
Marko, Salmi, Sirpa, Jalkanen
openaire   +2 more sources