Results 251 to 260 of about 1,424,595 (340)

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Vitamin K preserves gamma-glutamyl carboxylase activity against carbamylations in uremia: Implications for vascular calcification and adjunct therapies. [PDF]

Acta Physiol (Oxf)
Kaesler N, Kaushik S, Frisch J, Ziegler S, Grommes J, Gombert A, Roma LP, Kuppe C, Jankowski J, Floege J, de la Puente-Secades S, Kramann R, Jankowski V.   +12 more
europepmc   +1 more source

Effect of Crystallization Inhibitors on Vascular Calcifications Induced by Vitamin D A Pilot Study in Sprague-Dawley Rats

, 2007
F. Gráses, Pilar Sanchís, Joan Perelló, Bernat Isern, Rafael Prieto, Carlos Fernández-Palomeque, José Torres   +6 more
openalex   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Zinc Action in Vascular Calcification. [PDF]

Prev Nutr Food Sci
Kwon JH, Kim DK, Cho YE, Kwun IS.
europepmc   +1 more source

Differential effects of vitamin D receptor activators on vascular calcification in uremic rats

, 2007
Masahide Mizobuchi, Jane Finch, Daniel R. Martin, Eduardo Slatopolsky   +3 more
openalex   +1 more source

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Vascular Calcifications in Calcific Uremic Arteriolopathy [PDF]

Clinical Medical Image Library, 2016
openaire   +2 more sources

Understanding Vascular Calcification in Chronic Kidney Disease: Pathogenesis and Therapeutic Implications. [PDF]

Int J Mol Sci
Siracusa C, Carabetta N, Morano MB, Manica M, Strangio A, Sabatino J, Leo I, Castagna A, Cianflone E, Torella D, Andreucci M, Zicarelli MT, Musolino M, Bolignano D, Coppolino G, De Rosa S.   +15 more
europepmc   +1 more source

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

Advanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li, Hwan D. Kim, Allen C. Luo, Liyan Gong, Yonglin Zhu, Chin Nien Lee, Xuechong Hong, Christopher L. Sudduth, Michal Ad, Young‐Hyeon An, Mihn Jeong Park, Do‐Gyoon Kim, Arin K. Greene, Bonnie L. Padwa, Nathaniel S. Hwang, Ruei‐Zeng Lin, Juan M. Melero‐Martin   +16 more
wiley   +1 more source