Results 51 to 60 of about 289,601 (306)

Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.

PLoS ONE, 2015
Mast cell (MC) activation contributes considerably to immune responses, such as host protection and allergy. Cell surface immunoreceptors expressed on MCs play an important role in MC activation.
Kazumasa Kanemaru, Emiko Noguchi, Takahiro Tokunaga, Kei Nagai, Takashi Hiroyama, Yukio Nakamura, Satoko Tahara-Hanaoka, Akira Shibuya   +7 more
doaj   +1 more source

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. [PDF]

, 2012
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively.
Chen, Xiao Lei, Cheresh, David A, Lawson, Christine, Lim, Ssang-Taek, Miller, Nichol LG, Schlaepfer, David D, Tancioni, Isabelle, Uryu, Sean, Walsh, Colin T, Weis, Sara M   +9 more
core   +1 more source

Effect of Mitral Stenosis Severity on Blood Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 Levels

Majalah Kardiologi Indonesia, 2015
Background: Blood Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and Soluble Intercellular Adhesion Molecule-1 (sICAM-1) levels are increased in Mitral Stenosis (MS) patients, but whether this phenomenon is due to chronic rheumatic inflammation ...
Pramono Sigit, Yoga Yuniadi, Indriwanto Sakidjan   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia [PDF]

, 2014
Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease.
Dichek, D A, Dunn, Peter Francis, Libby, Peter, Newman, K D, Owens, J W, Schulick, A H, Sukhova, Galina K., Virmani, R   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse [PDF]

, 2017
Background & Aims Regeneration of the hepatic mass is crucial to liver repair. Proliferation of hepatic parenchyma is intimately dependent on angiogenesis and resident macrophage-derived cytokines.
Edelman, Elazer R, Melgar Lesmes, Pedro
core   +1 more source

Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction [PDF]

Journal of Leukocyte Biology, 2007
AbstractImmune complex (IC)-induced inflammation is mediated by inflammatory cell infiltration, a process that is highly regulated by expression of multiple adhesion molecules. The roles and interactions of ICAM-1 and VCAM-1, the major regulators of leukocyte firm adhesion, were examined in the cutaneous reverse-passive Arthus reaction using ICAM-1 ...
Hidemitsu, Orito, Manabu, Fujimoto, Nobuko, Ishiura, Koichi, Yanaba, Takashi, Matsushita, Minoru, Hasegawa, Fumihide, Ogawa, Kazuhiko, Takehara, Shinichi, Sato   +8 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study [PDF]

, 2002
Inflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease.
Bots, M.L. (Michiel), Breteler, M.M.B. (Monique), Hofman, A. (Albert), Kiliaan, A.J. (Amanda), Maat, M.P.M. (Moniek) de, Meijer, J. (John), Witteman, J.C.M. (Jacqueline)   +6 more
core