Results 31 to 40 of about 2,053,431 (310)

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

eLife, 2018
Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers and arrange suitably to shape functional vascular networks is poorly understood ...
Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt   +11 more
doaj   +1 more source

Single Cell Analysis in Vascular Biology

Frontiers in Cardiovascular Medicine, 2020
The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within tissues.
Nicholas W. Chavkin, Karen K. Hirschi, Karen K. Hirschi   +2 more
doaj   +1 more source

Pericytes in Vascular Development

Current Tissue Microenvironment Reports, 2020
Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation.
Laura Beth Payne, Maruf Hoque, Clifton Houk, Jordan Darden, John C. Chappell   +4 more
openaire   +3 more sources

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile [PDF]

, 2013
<p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both ...
AA Soyombo, AC Bradshaw, AC Bradshaw, AF Merrick, AH Baker, AL Parker, AL Parker, Alan L Parker, Andrew H Baker, Angela C Bradshaw, Audrey F Wright, B Vigl, C-C Liang, Christian Delles, DM Roberts, F Sakurai, F Vigant, K Doronin, Katie M White, KD Newman, M Hedman, M Hedman, M Jessup, MC Sprangers, MD Rekhter, MJE Havenga, MM Zanone, MO Hilutnen, N Inoue, O Kalyuzhniy, P Lemarchand, R Alba, R Alba, R Vogels, Raul Alba, RD Lopes, Robert A McDonald, RR Bradley, S Ishii, S Kuriyama, SA Nicklin, SD Carson, SJ George, SJ George, SM Sumida, SN Waddington, TD Henry, TW Johnson   +47 more
core   +2 more sources

Sustained Angiopoietin-2 Expression Disrupts Vessel Formation and Inhibits Glioma Growth

Neoplasia: An International Journal for Oncology Research, 2006
Systematic analyses of the expression of angiogenic regulators in cancer models should yield useful information for the development of novel therapies for malignant gliomas.
Ok-Hee Lee, Juan Fueyo, Jing Xu, W.K. Alfred Yung, Michael G. Lemoine, Frederick F. Lang, B. Nebiyou Bekele, Xian Zhou, Marta A. Alonso, Kenneth D. Aldape, Gregory N. Fuller, Candelaria Gomez-Manzano   +11 more
doaj   +1 more source

Uncoupling protein 2: a key player and a potential therapeutic target in vascular diseases [PDF]

, 2017
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative ...
Forte, Maurizio, Migliarino, Serena, Perelli, Marika, Pierelli, Giorgia, Rubattu, Speranza, Stanzione, Rosita, Volpe, Massimo   +6 more
core   +2 more sources

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

Vascular Development and Regeneration in the Mammalian Heart

Journal of Cardiovascular Development and Disease, 2016
Cardiovascular diseases including coronary artery disease are the leading cause of death worldwide. Unraveling the developmental origin of coronary vessels could offer important therapeutic implications for treatment of cardiovascular diseases.
Oscar M. Leung, Bin Zhou, Kathy O. Lui
doaj   +1 more source

The Phloem Intercalated With Xylem-Correlated 3 Receptor-Like Kinase Constitutively Interacts With Brassinosteroid Insensitive 1-Associated Receptor Kinase 1 and Is Involved in Vascular Development in Arabidopsis

Frontiers in Plant Science, 2022
Leucine-rich repeat receptor-like kinases (LRR-RLKs) play fundamental roles in cell-to-cell and plant-environment communication. LRR-RLKs can function as receptors perceiving endogenous or external ligands, or as coreceptors, which stabilize the complex,
Ke Xu, Ke Xu, Joris Jourquin, Joris Jourquin, Maria Fransiska Njo, Maria Fransiska Njo, Long Nguyen, Long Nguyen, Tom Beeckman, Tom Beeckman, Ana Ibis Fernandez, Ana Ibis Fernandez   +11 more
doaj   +1 more source

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

Cell Reports, 2017
Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ...
Tomoko Yamazaki, Ani Nalbandian, Yutaka Uchida, Wenling Li, Thomas D. Arnold, Yoshiaki Kubota, Seiji Yamamoto, Masatsugu Ema, Yoh-suke Mukouyama   +8 more
doaj   +1 more source