Results 1 to 10 of about 381,155 (160)

Vascular endothelial growth factor-C in activating vascular endothelial growth factor receptor-3 and chemokine receptor-4 in melanoma adhesion. [PDF]

J Cell Mol Med, 2022
AbstractVascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Hlophe YN, Joubert AM.
europepmc   +4 more sources

Association of serum vascular endothelial growth factor-C, vascular endothelial growth factor receptor-3, and insulin-like growth factor 1 levels with metastasis and prognosis in patients with nasopharyngeal carcinoma [PDF]

Frontiers in Oncology
ObjectiveTo investigate the association of serum levels of Vascular Endothelial Growth Factor-C (VEGFC), Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3), and Insulin-like Growth Factor 1 (IGF1) with metastasis and prognosis in patients with ...
Yongchun Li, Le Wang, Yutong Zhao, Jia Zhao, Wulin Wen   +4 more
doaj   +2 more sources

Analysis of research hotspots on the detection of vascular endothelial growth factor C and its receptor vascular endothelial growth factor receptor-3 in cervical squamous cell carcinoma [PDF]

Discover Oncology
Cervical squamous cell carcinoma (CSCC) remains a prevalent malignancy among women worldwide, with lymphatic metastasis critically influencing prognosis.
Yaowen Hu, Qun Fang
doaj   +2 more sources

Vascular endothelial growth factor-C and its receptor-3 signaling in tumorigenesis. [PDF]

3 Biotech, 2023
The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed by a range of human tumor cells in addition to lymphatic endothelial cells. Activating the VEGF-C/VEGFR-3 signaling enhances metastasis by promoting lymphangiogenesis and angiogenesis inside and around ...
Vimalraj S, Hariprabu KNG, Rahaman M, Govindasami P, Perumal K, Sekaran S, Ganapathy D.   +6 more
europepmc   +3 more sources

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. [PDF]

J Am Soc Nephrol, 2016
Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal tissue. Current therapies have focused on the cyst epithelium, and little is known about how the blood and lymphatic microvasculature modulates cystogenesis.
Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.   +9 more
europepmc   +6 more sources

Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
Because virtually all tissues contain blood vessels, the importance of hemevascularization has been long recognized in regenerative medicine and tissue engineering.
Khushbu Rauniyar, Sawan Kumar Jha, Michael Jeltsch, Michael Jeltsch   +3 more
doaj   +2 more sources

Dual role of vascular endothelial growth factor-C in post-stroke recovery. [PDF]

J Exp Med
Cerebrospinal fluid (CSF), antigens, and antigen-presenting cells drain from the central nervous system (CNS) into lymphatic vessels near the cribriform plate and dura, yet the role of these vessels during stroke is unclear. Using a mouse model of ischemic stroke, transient middle cerebral artery occlusion (tMCAO), we demonstrate stroke-induced ...
Choi YH, Hsu M, Laaker C, Port J, Kovács KG, Herbath M, Yang H, Cismaru P, Johnson AM, Spellman B, Wigand K, Sandor M, Fabry Z.   +12 more
europepmc   +3 more sources

Vascular endothelial growth factor C treatment for mouse hind limb lymphatic revascularization. [PDF]

Vet Med Sci, 2019
AbstractSpontaneous lymphatic revascularization is a challenge and the establishment of new therapeutic strategies may improve life quality for patients suffering from lymphatic disorders. This study was designed to verify if VEGFC treatment improves lymphatic vascularization in a time‐dependent manner in mouse hindlimb (HL) after resection of the ...
Ferrão JSP, Bonfim Neto AP, da Fonseca VU, Sousa LMMC, Papa PC.   +4 more
europepmc   +4 more sources

Vascular endothelial growth factor-C: its unrevealed role in fibrogenesis.

Am J Physiol Heart Circ Physiol, 2014
Vascular endothelial growth factor (VEGF)-C is a key mediator of lymphangiogenesis. Our recent study shows that VEGF-C/VEGF receptors (VEGFR)-3 are significantly increased in the infarcted rat myocardium, where VEGFR-3 is expressed not only in lymph ducts but also in myofibroblasts, indicating that VEGF-C has an unrevealed role in fibrogenesis during ...
Zhao T, Zhao W, Meng W, Liu C, Chen Y, Sun Y.   +5 more
europepmc   +4 more sources

Bisacurone gel ameliorated burn wounds in experimental rats via its anti-inflammatory, antioxidant, and angiogenic properties [PDF]

Acta Cirúrgica Brasileira, 2023
Purpose: To investigate putative mechanism of wound healing for chitosan-based bisacurone gel against secondary burn wounds in rats. Methods: A second-degree burn wound with an open flame using mixed fuel (2 mL, 20 seconds) was induced in Sprague Dawley
Zengqiang Yan, Shuyan Li, Zhenzhong Gong
doaj   +1 more source