Results 11 to 20 of about 27,631,015 (306)

Co-regulatory potential of vascular endothelial growth factor–A and vascular endothelial growth factor–C in thyroid carcinoma [PDF]

Human Pathology, 2013
Vascular endothelial growth factor (VEGF) promotes growth of blood or lymphatic vessels. The aim of the current study is to identify relationships between VEGF-A and VEGF-C, and their impact in angiogenesis and metastases in thyroid cancers. VEGF-A and VEGF-C mRNA and protein expression was investigated in 136 thyroid cancers (123 papillary thyroid ...
Salajegheh, Ali, Pakneshan, Sahar, Rahman, Atiqur, Dolan-Evans, Elliot, Zhang, Sheldon, Kwong, Esther, Gopalan, Vinod, Lo, Chung-Yau, Smith, Robert Anthony, Lam, Alfred King-Yin   +9 more
openaire   +6 more sources

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor-C in locally advanced breast cancer patients

Clinics, 2011
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors.
Luiz Gustavo Oliveira Brito, Viviane Fernandes Schiavon, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi, Fernanda Maris Peria, Heitor Ricardo Cosiski Marana   +5 more
doaj   +2 more sources

Vascular endothelial growth factor-C in activating vascular endothelial growth factor receptor-3 and chemokine receptor-4 in melanoma adhesion. [PDF]

J Cell Mol Med, 2022
AbstractVascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Hlophe YN, Joubert AM.
europepmc   +4 more sources

Vascular endothelial growth factor-C and its receptor-3 signaling in tumorigenesis. [PDF]

3 Biotech, 2023
The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed by a range of human tumor cells in addition to lymphatic endothelial cells. Activating the VEGF-C/VEGFR-3 signaling enhances metastasis by promoting lymphangiogenesis and angiogenesis inside and around ...
Vimalraj S, Hariprabu KNG, Rahaman M, Govindasami P, Perumal K, Sekaran S, Ganapathy D.   +6 more
europepmc   +3 more sources

Uses of Vascular Endothelial Growth Factor C as a Lung Adenocarcinoma Prognostic Biomarker. [PDF]

World J Oncol, 2023
Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a leading cause of death worldwide. Vascular endothelial growth factor C (VEGF-C) has been identified as a prognosis prediction marker for LUAD. However, VEGF-C protein expression does not appear to significantly relate to LUAD patient survival in several studies.We carried out a ...
Chen S, Pan TY, Wu X, Li T, Wei Y, He HL, Zhou XM, Wang Q, Zhu JP.   +8 more
europepmc   +3 more sources

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases. [PDF]

J Am Soc Nephrol, 2016
Polycystic kidney diseases (PKD) are genetic disorders characterized by progressive epithelial cyst growth leading to destruction of normally functioning renal tissue. Current therapies have focused on the cyst epithelium, and little is known about how the blood and lymphatic microvasculature modulates cystogenesis.
Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.   +9 more
europepmc   +7 more sources

Expression of vascular endothelial growth factor C in human pterygium [PDF]

Histochemistry and Cell Biology, 2012
Vascular endothelial growth factor C (VEGF-C) and its receptor VEGFR-3 mediate lymphangiogenesis. In this study, we analyzed the expression of VEGF-C and VEGFR-3 as well as lymphatic vessels in the pterygium and normal conjunctiva of humans. Fifteen primary nasal pterygia and three normal bulbar conjunctivas, surgically removed, were examined in this ...
Fukuhara, Junichi, Kase, Satoru, Ohashi, Tsutomu, Ando, Ryo, Dong, Zhenyu, Noda, Kousuke, Ohguchi, Takeshi, Kanda, Atsuhiro, Ishida, Susumu   +8 more
openaire   +4 more sources

Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells [PDF]

Angiogenesis, 2013
Radiation therapy after lymph node dissection increases the risk of developing painful and incurable lymphedema in breast cancer patients. Lymphedema occurs when lymphatic vessels become unable to maintain proper fluid balance. The sensitivity of lymphatic endothelial cells (LECs) to ionizing radiation has not been reported to date.
Cristina T, Kesler, Angera H, Kuo, Hon-Kit, Wong, David J, Masuck, Jennifer L, Shah, Kevin R, Kozak, Kathryn D, Held, Timothy P, Padera   +7 more
openaire   +2 more sources

Dual role of vascular endothelial growth factor-C in post-stroke recovery. [PDF]

J Exp Med
Cerebrospinal fluid (CSF), antigens, and antigen-presenting cells drain from the central nervous system (CNS) into lymphatic vessels near the cribriform plate and dura, yet the role of these vessels during stroke is unclear. Using a mouse model of ischemic stroke, transient middle cerebral artery occlusion (tMCAO), we demonstrate stroke-induced ...
Choi YH, Hsu M, Laaker C, Port J, Kovács KG, Herbath M, Yang H, Cismaru P, Johnson AM, Spellman B, Wigand K, Sandor M, Fabry Z.   +12 more
europepmc   +3 more sources

Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2 [PDF]

British Journal of Ophthalmology, 2006
To determine vascular endothelial growth factor C (VEGF-C) expression in retinal endothelial cells, its antiapoptotic potential and its putative role in diabetic retinopathy.Cultured retinal endothelial cells and pericytes were exposed to tumour necrosis factor (TNF)alpha and VEGF-C expression determined by reverse transcriptase-polymerase chain ...
Bojun, Zhao, Gill, Smith, Jun, Cai, Aihua, Ma, Mike, Boulton   +4 more
openaire   +2 more sources